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Table 4 Organ distribution of radioactivity in mice after intravenous injection of [18F]MC225

From: Automated synthesis, preclinical toxicity, and radiation dosimetry of [18F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier

 

Injected dose/organ (%) *

 

5 min

15 min

30 min

60 min

180 min

360 min

Heart

0.44 ± 0.06

0.26 ± 0.00

0.22 ± 0.01

0.22 ± 0.03

0.18 ± 0.01

0.14 ± 0.01

Lung

3.48 ± 0.93

1.61 ± 0.05

1.08 ± 0.12

0.79 ± 0.06

0.35 ± 0.03

0.21 ± 0.06

Liver

18.55 ± 1.70

24.21 ± 0.86

21.31 ± 1.66

17.92 ± 1.07

7.53 ± 0.57

5.18 ± 0.75

Pancreas

2.35 ± 0.27

3.10 ± 0.33

3.62 ± 0.28

4.44 ± 0.88

6.37 ± 1.05

6.68 ± 1.86

Spleen

0.55 ± 0.12

0.48 ± 0.07

0.47 ± 0.03

0.34 ± 0.08

0.17 ± 0.04

0.08 ± 0.01

Kidney

7.36 ± 0.70

5.36 ± 0.59

4.07 ± 0.89

2.88 ± 0.34

1.47 ± 0.32

1.40 ± 0.35

Stomach

2.57 ± 0.41

3.36 ± 0.38

3.02 ± 0.52

3.80 ± 0.61

2.60 ± 0.60

2.01 ± 0.51

Small intestine

7.20 ± 0.52

9.15 ± 0.71

12.38 ± 1.57

15.76 ± 3.32

21.98 ± 4.21

14.85 ± 1.62

Large intestine

3.50 ± 0.41

4.35 ± 1.10

3.58 ± 0.29

4.87 ± 1.75

9.79 ± 3.34

20.19 ± 2.26

Testis

0.20 ± 0.03

0.29 ± 0.04

0.28 ± 0.03

0.33 ± 0.07

0.42 ± 0.04

0.39 ± 0.09

Brain

0.50 ± 0.05

0.54 ± 0.14

0.45 ± 0.01

0.40 ± 0.06

0.31 ± 0.03

0.23 ± 0.02

Bladder

0.13 ± 0.08

0.12 ± 0.03

0.06 ± 0.02

0.26 ± 0.15

0.12 ± 0.10

0.38 ± 0.20

Urine

0.10 ± 0.01

0.43 ± 0.19

1.34 ± 0.25

2.88 ± 0.88

11.35 ± 0.57

17.26 ± 2.26

Bladder + urine

0.24 ± 0.07

0.56 ± 0.16

1.40 ± 0.26

3.13 ± 0.97

11.48 ± 0.60

17.64 ± 2.11

  1. *Mean ± S.D. (n = 4)