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Table 4 Organ distribution of radioactivity in mice after intravenous injection of [18F]MC225

From: Automated synthesis, preclinical toxicity, and radiation dosimetry of [18F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier

  Injected dose/organ (%) *
  5 min 15 min 30 min 60 min 180 min 360 min
Heart 0.44 ± 0.06 0.26 ± 0.00 0.22 ± 0.01 0.22 ± 0.03 0.18 ± 0.01 0.14 ± 0.01
Lung 3.48 ± 0.93 1.61 ± 0.05 1.08 ± 0.12 0.79 ± 0.06 0.35 ± 0.03 0.21 ± 0.06
Liver 18.55 ± 1.70 24.21 ± 0.86 21.31 ± 1.66 17.92 ± 1.07 7.53 ± 0.57 5.18 ± 0.75
Pancreas 2.35 ± 0.27 3.10 ± 0.33 3.62 ± 0.28 4.44 ± 0.88 6.37 ± 1.05 6.68 ± 1.86
Spleen 0.55 ± 0.12 0.48 ± 0.07 0.47 ± 0.03 0.34 ± 0.08 0.17 ± 0.04 0.08 ± 0.01
Kidney 7.36 ± 0.70 5.36 ± 0.59 4.07 ± 0.89 2.88 ± 0.34 1.47 ± 0.32 1.40 ± 0.35
Stomach 2.57 ± 0.41 3.36 ± 0.38 3.02 ± 0.52 3.80 ± 0.61 2.60 ± 0.60 2.01 ± 0.51
Small intestine 7.20 ± 0.52 9.15 ± 0.71 12.38 ± 1.57 15.76 ± 3.32 21.98 ± 4.21 14.85 ± 1.62
Large intestine 3.50 ± 0.41 4.35 ± 1.10 3.58 ± 0.29 4.87 ± 1.75 9.79 ± 3.34 20.19 ± 2.26
Testis 0.20 ± 0.03 0.29 ± 0.04 0.28 ± 0.03 0.33 ± 0.07 0.42 ± 0.04 0.39 ± 0.09
Brain 0.50 ± 0.05 0.54 ± 0.14 0.45 ± 0.01 0.40 ± 0.06 0.31 ± 0.03 0.23 ± 0.02
Bladder 0.13 ± 0.08 0.12 ± 0.03 0.06 ± 0.02 0.26 ± 0.15 0.12 ± 0.10 0.38 ± 0.20
Urine 0.10 ± 0.01 0.43 ± 0.19 1.34 ± 0.25 2.88 ± 0.88 11.35 ± 0.57 17.26 ± 2.26
Bladder + urine 0.24 ± 0.07 0.56 ± 0.16 1.40 ± 0.26 3.13 ± 0.97 11.48 ± 0.60 17.64 ± 2.11
  1. *Mean ± S.D. (n = 4)