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EJNMMI Research

Table 1 Theoretical lower limit of detection (LLD) for PET/CT and PET/MRI with respect to cell number and specific activity

From: Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI

 

6-well plates

3 × 3 cubic-well

LLDPET/MRI

LLDPET/CT

LLDPET/MRI

LLDPET/CT

Cell number

5.24 × 105 (1.05 × 104)*

5.88 × 105 (1.07 × 104)*

4.56 × 105 (2.84 × 103)*

4.83 × 105 (3.22 × 103)*

Specific activity [kBq/106 cells]

3.26 (0.07)*

3.72 (0.07)*

5.46 (0.03)*

5.25 (0.04)*

  1. *Values in parentheses indicate the theoretical LLD values according to the Rose criterion (CNR = 5) as a threshold for detectability
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