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Table 1 Theoretical lower limit of detection (LLD) for PET/CT and PET/MRI with respect to cell number and specific activity

From: Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI

  6-well plates 3 × 3 cubic-well
LLDPET/MRI LLDPET/CT LLDPET/MRI LLDPET/CT
Cell number 5.24 × 105 (1.05 × 104)* 5.88 × 105 (1.07 × 104)* 4.56 × 105 (2.84 × 103)* 4.83 × 105 (3.22 × 103)*
Specific activity [kBq/106 cells] 3.26 (0.07)* 3.72 (0.07)* 5.46 (0.03)* 5.25 (0.04)*
  1. *Values in parentheses indicate the theoretical LLD values according to the Rose criterion (CNR = 5) as a threshold for detectability