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Fig. 6 | EJNMMI Research

Fig. 6

From: Radiobiological and dosimetric assessment of DNA-intercalated 99mTc-complexes bearing acridine orange derivatives

Fig. 6

Activity-dependent DNA damage induced by 99mTc-C3 and 99mTc-C5 in PC3 cells, after 24 h incubation at 37 °C. Cells were incubated with 0, 0.37, 0.74, 1.85, and 3.7 MBq of HPLC purified radiocomplexes. a Average number of foci per nuclei in PC3 cells exposed to 99mTc-C3, 99mTc-C5, and [99mTcO4]. The results were normalized to control samples (i.e., non-irradiated cells). The data correspond to means ± standard deviations of 3 replicates. b Fluorescence images of PC3 cells exposed to 0.37–3.7 MBq of 99mTc-C3. Cells were immunostained for γ-H2AX. DAPI was used to visualize the nuclei

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