Fig. 1

Longitudinal PET imaging following ⁸⁹Zr-T injection in subcutaneously implanted HER2+/ER− JIMT-1 bearing mice. a Representative maximum intensity projection (MIP) images of the same mouse imaged at 24, 48, 72, 144, and 168 h post-injection of ⁸⁹Zr-T. Images are all scaled at the same saturation level (0 to 15 %IA/g). b PET-derived ⁸⁹Zr-T uptake in %IA/g of assessable tissues from 24 to 168 h post-injection. Blood uptake was estimated from signals originating from the heart cavity. c Tumor-to-muscle and tumor-to-blood ratios at all assessed time points. *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001