Fig. 4

Coronal brain slices of an untreated (left column) and dexamethasone (Dex)-treated U87 bearing rat (right column). Histological staining (DAPI) (a, b), Evans blue staining (c, d) and ⁶⁸Ga-PSMA autoradiography (e, f). The untreated animal shows a strong extravasation of Evans blue into the tumor tissue indicating BBB disruption (c). In contrast, the Dex-treated animal shows little extravasation of Evans blue into tumor tissue indicating a restoration of the BBB after Dex treatment (d). ⁶⁸Ga-PSMA autoradiography shows an unchanged prominent spherical tracer binding at the tumor rim both in the untreated animal (e) and after Dex treatment (f)