Fig. 4

[^99mTc]Tc-PSMA-I&S-SPECT/CT in primary high risk PCa. a 71-year-old man with Gleason 9 PCa (PSA 46 ng/ml). Apart from the primary tumor (green arrow), increased PSMA expression was detected in one lymph node in the right iliac region and in the left inguinal region (red arrows)(TxN1M0). b 77-year-old man with Gleason 9 PCa (PSA 80 ng/ml). PSMA expression was increased in the primary tumor only (green arrow), no metastases were detected (TxN0M0)