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Table 1 Biodistribution of 68Ga-NOTA-TATE and 68Ga-DOTA-TATE in percentage of injected dose per gramme of organ at 15 min, 0.5 h, 1 h and 2 h postinjection in mice bearing AR42J tumours

From: Comparative evaluation of 68Ga-labelled TATEs: the impact of chelators on imaging

%ID/g of organ or tissue
Organ/tissue68Ga-DOTA-TATE68Ga-NOTA-TATE
15 min0.5 h1 h2 h15 min0.5 h1 h2 h
Blood3.03 ± 1.961.32 ± 0.390.35 ± 0.200.05 ± 0.023.25 ± 1.061.01 ± 0.420.58 ± 0.240.07 ± 0.06
Liver1.27 ± 0.770.61 ± 0.350.34 ± 0.250.08 ± 0.071.19 ± 0.540.43 ± 0.230.07 ± 0.040.04 ± 0.02
Spleen3.84 ± 4.031.48 ± 0.841.92 ± 1.750.21 ± 0.190.19 ± 0.080.13 ± 0.110.12 ± 0.060.03 ± 0.01
Lungs5.10 ± 5.222.86 ± 1.474.62 ± 3.420.98 ± 0.223.64 ± 1.560.21 ± 0.170.64 ± 0.410.48 ± 0.21
Kidney10.35 ± 8.898.12 ± 2.712.82 ± 2.541.49 ± 0.5717.1 ± 6.394.23 ± 2.733.79 ± 2.161.69 ± 1.02
Gallbladder1.47 ± 0.620.79 ± 0.480.52 ± 0.310.11 ± 0.063.62 ± 1.946.21 ± 2.691.83 ± 0.841.61 ± 0.67
Stomach4.24 ± 2.660.98 ± 0.494.26 ± 2.580.52 ± 0.390.19 ± 0.133.55 ± 1.831.61 ± 1.031.11 ± 0.21
Intestines1.56 ± 1.471.58 ± 1.770.91 ± 0.520.23 ± 0.150.07 ± 0.040.03 ± 0.020.21 ± 0.090.13 ± 0.07
Skeleton1.94 ± 0.811.10 ± 0.630.80 ± 0.730.17 ± 0.062.14 ± 1.411.46 ± 0.370.85 ± 0.380.13 ± 0.07
Muscle1.18 ± 1.260.60 ± 0.450.07 ± 0.020.04 ± 0.010.26 ± 0.030.47 ± 0.260.08 ± 0.060.03 ± 0.01
Tumour3.13 ± 1.753.62 ± 1.943.14 ± 2.072.3 ± 1.343.24 ± 1.033.97 ± 2.243.16 ± 1.921.33 ± 0.96
Tumour/kidney0.300.451.111.540.180.940.810.79
T/NT2.656.0344.8657.5012.468.4539.544.3
  1. T/NT tumour/muscle