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Table 1 Biodistribution of 68Ga-NOTA-TATE and 68Ga-DOTA-TATE in percentage of injected dose per gramme of organ at 15 min, 0.5 h, 1 h and 2 h postinjection in mice bearing AR42J tumours

From: Comparative evaluation of 68Ga-labelled TATEs: the impact of chelators on imaging

%ID/g of organ or tissue

Organ/tissue

68Ga-DOTA-TATE

68Ga-NOTA-TATE

15 min

0.5 h

1 h

2 h

15 min

0.5 h

1 h

2 h

Blood

3.03 ± 1.96

1.32 ± 0.39

0.35 ± 0.20

0.05 ± 0.02

3.25 ± 1.06

1.01 ± 0.42

0.58 ± 0.24

0.07 ± 0.06

Liver

1.27 ± 0.77

0.61 ± 0.35

0.34 ± 0.25

0.08 ± 0.07

1.19 ± 0.54

0.43 ± 0.23

0.07 ± 0.04

0.04 ± 0.02

Spleen

3.84 ± 4.03

1.48 ± 0.84

1.92 ± 1.75

0.21 ± 0.19

0.19 ± 0.08

0.13 ± 0.11

0.12 ± 0.06

0.03 ± 0.01

Lungs

5.10 ± 5.22

2.86 ± 1.47

4.62 ± 3.42

0.98 ± 0.22

3.64 ± 1.56

0.21 ± 0.17

0.64 ± 0.41

0.48 ± 0.21

Kidney

10.35 ± 8.89

8.12 ± 2.71

2.82 ± 2.54

1.49 ± 0.57

17.1 ± 6.39

4.23 ± 2.73

3.79 ± 2.16

1.69 ± 1.02

Gallbladder

1.47 ± 0.62

0.79 ± 0.48

0.52 ± 0.31

0.11 ± 0.06

3.62 ± 1.94

6.21 ± 2.69

1.83 ± 0.84

1.61 ± 0.67

Stomach

4.24 ± 2.66

0.98 ± 0.49

4.26 ± 2.58

0.52 ± 0.39

0.19 ± 0.13

3.55 ± 1.83

1.61 ± 1.03

1.11 ± 0.21

Intestines

1.56 ± 1.47

1.58 ± 1.77

0.91 ± 0.52

0.23 ± 0.15

0.07 ± 0.04

0.03 ± 0.02

0.21 ± 0.09

0.13 ± 0.07

Skeleton

1.94 ± 0.81

1.10 ± 0.63

0.80 ± 0.73

0.17 ± 0.06

2.14 ± 1.41

1.46 ± 0.37

0.85 ± 0.38

0.13 ± 0.07

Muscle

1.18 ± 1.26

0.60 ± 0.45

0.07 ± 0.02

0.04 ± 0.01

0.26 ± 0.03

0.47 ± 0.26

0.08 ± 0.06

0.03 ± 0.01

Tumour

3.13 ± 1.75

3.62 ± 1.94

3.14 ± 2.07

2.3 ± 1.34

3.24 ± 1.03

3.97 ± 2.24

3.16 ± 1.92

1.33 ± 0.96

Tumour/kidney

0.30

0.45

1.11

1.54

0.18

0.94

0.81

0.79

T/NT

2.65

6.03

44.86

57.50

12.46

8.45

39.5

44.3

  1. T/NT tumour/muscle