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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: In vivo long-lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine

Fig. 1

An example of 2D images showing 4-[18F]ADAM distribution obtained 60–90 min after administration of 4-[18F]ADAM in control animals (upper panel) and those treated with 5 mg/kg of METH (middle panel) and 10 mg/kg of METH (lower panel). Higher 4-[18F]ADAM accumulations were found in the amygdala, caudate/putamen, midbrain, and hippocampus. Lower accumulation of radioactivity was found in the cerebellum. The accumulation of 4-[18F]ADAM illustrates decreased SERT availability in the METH-induced groups. The accumulated radioactivity was expressed as a percentage of the injection dose/tissue gram (%ID/g). fctx, frontal cortex; str, striatum (caudate/putamen); tha, thalamus; mid, midbrain; hip, hippocampus; cr, cerebellum

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