Table 2 Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)
Patient (administered activity in GBq) | SMIRD (mGy) | MC1 (mGy) | MC2 (mGy) | Bone lesion load (ml) | Time-integrated tumor uptake (GBq × s/ml) | Time-integrated ROB retention (GBq × s/ml) |
|---|---|---|---|---|---|---|
P1 (3.7) | 30 | 493 | 81 | 402 | 141 | 3 |
P2 (3.7) | 41 | 109 | 109 | 33 | 87 | 4 |
P3 (3.7) | 52 | 274 | 137 | 448 | 59 | 5 |
P4 (3.7) | 63 | 3192 | 281 | 1123 | 609 | 4 |
P5 (6.0) | 120 | 2139 | 515 | 1124 | 523 | 17 |
P6 (6.0) | 36 | 22 | 22 | 50 | 91 | 6 |
P7 (6.0) | 150 | 5595 | 635 | 727 | 1130 | 26 |
P8 (6.0) | 46 | 1123 | 225 | 1298 | 159 | 10 |
P9 (6.0) | 40 | 684 | 202 | 836 | 128 | 9 |
P10 (6.1) | 66 | 782 | 347 | 1383 | 84 | 17 |
P11 (6.1) | 36 | 403 | 206 | 467 | 64 | 9 |