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Table 2 Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)

From: 3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT

Patient (administered activity in GBq) SMIRD (mGy) MC1 (mGy) MC2 (mGy) Bone lesion load (ml) Time-integrated tumor uptake (GBq × s/ml) Time-integrated ROB retention (GBq × s/ml)
P1 (3.7) 30 493 81 402 141 3
P2 (3.7) 41 109 109 33 87 4
P3 (3.7) 52 274 137 448 59 5
P4 (3.7) 63 3192 281 1123 609 4
P5 (6.0) 120 2139 515 1124 523 17
P6 (6.0) 36 22 22 50 91 6
P7 (6.0) 150 5595 635 727 1130 26
P8 (6.0) 46 1123 225 1298 159 10
P9 (6.0) 40 684 202 836 128 9
P10 (6.1) 66 782 347 1383 84 17
P11 (6.1) 36 403 206 467 64 9
  1. Additionally, bone lesion load, time-integrated tumor uptake, and ROB retention are provided for each patient