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Table 4 Equivalent doses of [18F]DiFA, [18F]FMISO, [18F]FAZA, [18F]HX4, and [18F]FETNIM to target organs

From: Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO

Target organs Tracer
[18F]DiFA (2-h void) [18F]FMISO [13] (2-h void) [18F]FAZA [11] (2-h void) [18F]HX4 [14] (1-h void) [18F]FETNIM [15] (2-h void)
Adrenals 0.009 ± 0.000 0.017 0.012 ± 0.001 0.009 ± 0.001 0.012
Brain 0.004 ± 0.000 0.009 0.004 ± 0.001 0.005 ± 0.001 0.006
Breasts 0.006 ± 0.000 0.012 0.009 ± 0.001 0.006 ± 0.001 0.007
Gallbladder wall 0.014 ± 0.002 0.015 0.013 ± 0.004 0.024 ± 0.007 0.014
LLI wall 0.013 ± 0.001 0.014 0.013 ± 0.006 0.022 ± 0.002 0.012
Small intestine 0.015 ± 0.001 0.013 0.012 ± 0.005 0.015 ± 0.000 0.012
Stomach wall 0.009 ± 0.000 0.013 0.012 ± 0.001 0.009 ± 0.001 0.012
ULI wall 0.015 ± 0.001 0.014 0.013 ± 0.002 0.016 ± 0.003 0.014
Heart wall 0.008 ± 0.000 0.019 0.018 ± 0.001 0.009 ± 0.001 0.011
Kidneys 0.018 ± 0.003 0.016 0.017 ± 0.002 0.019 ± 0.002 0.027
Liver 0.011 ± 0.001 0.018 0.016 ± 0.003 0.014 ± 0.003 0.024
Lungs 0.008 ± 0.000 0.010 0.011 ± 0.008 0.008 ± 0.001 0.008
Muscle 0.008 ± 0.000 0.014 0.011 ± 0.009 0.008 ± 0.001 0.012
Ovaries 0.012 ± 0.000 0.018 0.014 ± 0.001 0.012 ± 0.001 0.013
Pancreas 0.012 ± 0.002 0.018 0.013 ± 0.002 0.010 ± 0.001 0.019
Red marrow 0.014 ± 0.001 0.011 0.011 ± 0.001 0.008 ± 0.001 0.012
Osteogenic cells 0.014 ± 0.000 0.008 0.011 ± 0.002 0.012 ± 0.001 0.011
Skin 0.006 ± 0.000 0.005 0.008 ± 0.001 0.006 ± 0.001 0.007
Spleen 0.010 ± 0.002 0.016 0.017 ± 0.008 0.009 ± 0.001 0.020
Testes 0.009 ± 0.000 0.015 0.004 ± 0.001 0.009 ± 0.001 0.010
Thymus 0.007 ± 0.000 0.016 0.011 ± 0.003 0.008 ± 0.001 0.009
Thyroid 0.007 ± 0.000 0.015 0.010 ± 0.001 0.008 ± 0.001 0.009
Urinary bladder wall 0.095 ± 0.014 0.021 0.047 ± 0.008 0.085 ± 0.010 0.062
Uterus 0.015 ± 0.001 0.018 0.020 ± 0.001 0.014 ± 0.001 0.015
Total body 0.009 ± 0.000 0.013 0.012 ± 0.002 0.008 ± 0.001 0.011
Effective dose 0.014 ± 0.001 0.013 0.013 ± 0.004 0.014 ± 0.001 0.015
  1. LLI lower large intestine, ULI upper large intestine. The data are mean ± SD/mean, mSv/MBq, n = 6 subjects.