Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO

Watanabe, Shiro; Shiga, Tohru; Hirata, Kenji; Magota, Keiichi; Okamoto, Shozo; Toyonaga, Takuya; Higashikawa, Kei; Yasui, Hironobu; Kobayashi, Jun; Nishijima, Ken-ichi; Iseki, Ken; Matsumoto, Hiroki; Kuge, Yuji; Tamaki, Nagara

doi:10.1186/s13550-019-0525-6

EJNMMI Research

Table 4 Equivalent doses of [¹⁸F]DiFA, [¹⁸F]FMISO, [¹⁸F]FAZA, [¹⁸F]HX4, and [¹⁸F]FETNIM to target organs

From: Biodistribution and radiation dosimetry of the novel hypoxia PET probe [¹⁸F]DiFA and comparison with [¹⁸F]FMISO

Target organs	Tracer
Target organs	[¹⁸F]DiFA (2-h void)	[¹⁸F]FMISO [13] (2-h void)	[¹⁸F]FAZA [11] (2-h void)	[¹⁸F]HX4 [14] (1-h void)	[¹⁸F]FETNIM [15] (2-h void)
Adrenals	0.009 ± 0.000	0.017	0.012 ± 0.001	0.009 ± 0.001	0.012
Brain	0.004 ± 0.000	0.009	0.004 ± 0.001	0.005 ± 0.001	0.006
Breasts	0.006 ± 0.000	0.012	0.009 ± 0.001	0.006 ± 0.001	0.007
Gallbladder wall	0.014 ± 0.002	0.015	0.013 ± 0.004	0.024 ± 0.007	0.014
LLI wall	0.013 ± 0.001	0.014	0.013 ± 0.006	0.022 ± 0.002	0.012
Small intestine	0.015 ± 0.001	0.013	0.012 ± 0.005	0.015 ± 0.000	0.012
Stomach wall	0.009 ± 0.000	0.013	0.012 ± 0.001	0.009 ± 0.001	0.012
ULI wall	0.015 ± 0.001	0.014	0.013 ± 0.002	0.016 ± 0.003	0.014
Heart wall	0.008 ± 0.000	0.019	0.018 ± 0.001	0.009 ± 0.001	0.011
Kidneys	0.018 ± 0.003	0.016	0.017 ± 0.002	0.019 ± 0.002	0.027
Liver	0.011 ± 0.001	0.018	0.016 ± 0.003	0.014 ± 0.003	0.024
Lungs	0.008 ± 0.000	0.010	0.011 ± 0.008	0.008 ± 0.001	0.008
Muscle	0.008 ± 0.000	0.014	0.011 ± 0.009	0.008 ± 0.001	0.012
Ovaries	0.012 ± 0.000	0.018	0.014 ± 0.001	0.012 ± 0.001	0.013
Pancreas	0.012 ± 0.002	0.018	0.013 ± 0.002	0.010 ± 0.001	0.019
Red marrow	0.014 ± 0.001	0.011	0.011 ± 0.001	0.008 ± 0.001	0.012
Osteogenic cells	0.014 ± 0.000	0.008	0.011 ± 0.002	0.012 ± 0.001	0.011
Skin	0.006 ± 0.000	0.005	0.008 ± 0.001	0.006 ± 0.001	0.007
Spleen	0.010 ± 0.002	0.016	0.017 ± 0.008	0.009 ± 0.001	0.020
Testes	0.009 ± 0.000	0.015	0.004 ± 0.001	0.009 ± 0.001	0.010
Thymus	0.007 ± 0.000	0.016	0.011 ± 0.003	0.008 ± 0.001	0.009
Thyroid	0.007 ± 0.000	0.015	0.010 ± 0.001	0.008 ± 0.001	0.009
Urinary bladder wall	0.095 ± 0.014	0.021	0.047 ± 0.008	0.085 ± 0.010	0.062
Uterus	0.015 ± 0.001	0.018	0.020 ± 0.001	0.014 ± 0.001	0.015
Total body	0.009 ± 0.000	0.013	0.012 ± 0.002	0.008 ± 0.001	0.011
Effective dose	0.014 ± 0.001	0.013	0.013 ± 0.004	0.014 ± 0.001	0.015

LLI lower large intestine, ULI upper large intestine. The data are mean ± SD/mean, mSv/MBq, n = 6 subjects.

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