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Table 2 Absorbed dose estimations of 152Tb-CHX-DTPA-scFv78-Fc in mice. The table reports dosimetry results obtained with the microPET-based method, as compared with the dose extrapolation from 111In-CHX-DTPA-scFv78-Fc biodistribution data. On the right, the relative percent difference between the two methods is given

From: Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice

Target organ Absorbed doses (mGy/MBq)
microPET-based Biodistribution-based   Relative difference (%)
Mean dose Std dev. Mean dose Std dev.
Brain 6.34E + 01 2.84E + 01 3.94E + 01 1.27E + 01 60.98
Large intestine 3.63E + 02 9.36E + 01 2.34E + 02 6.30E + 01 54.91
Small intestine 3.45E + 02 8.84E + 01 3.29E + 02 6.00E + 01 4.71
Stomach wall 4.66E + 02 3.43E + 02 1.09E + 02 3.57E + 01 327.75
Heart wall 6.28E + 02 1.41E + 02 3.31E + 02 7.70E + 01 89.65
Kidneys 3.32E + 02 5.10E + 01 3.89E + 02 8.40E + 01 − 14.65
Liver 5.90E + 02 1.27E + 02 5.24E + 02 9.70E + 01 12.60
Lungs 3.20E + 02 4.58E + 01 1.47E + 02 4.00E + 01 117.86
Pancreas 2.24E + 02 2.56E + 01 3.60E + 02 7.50E + 01 − 37.78
Skeleton 1.11E + 02 2.27E + 01 6.57E + 01 1.81E + 01 68.99
Spleen 9.48E + 01 2.62E + 01 6.92E + 02 1.23E + 02 − 86.30
Testes 6.68E + 01 2.87E + 01 4.10E + 01 1.31E + 01 62.87
Thyroid 7.22E + 01 2.93E + 01 4.39E + 01 1.40E + 01 64.46
Urinary bladder 8.85E + 01 3.01E + 01 5.13E + 01 1.54E + 01 72.56
Total body 1.58E + 02 3.34E + 01 9.99E + 01 2.50E + 01 58.41
Tumor 2.14E + 02 6.94E + 01 2.60E + 02 7.23E + 01 − 17.66
  1. Indicates organs that were segmented on microPET/CT imaging, for which the comparison between dose obtained with the two methods appears more meaningful. As regards dosimetry data to the heart, however, it should be noted that imaging-based data were obtained by manual contouring of both the heart wall and the heart content (see example of image segmentation in Fig. 2)