Table 2 Absorbed dose estimations of 152Tb-CHX-DTPA-scFv78-Fc in mice. The table reports dosimetry results obtained with the microPET-based method, as compared with the dose extrapolation from 111In-CHX-DTPA-scFv78-Fc biodistribution data. On the right, the relative percent difference between the two methods is given
From: Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice
Target organ | Absorbed doses (mGy/MBq) | ||||
|---|---|---|---|---|---|
microPET-based | Biodistribution-based | Relative difference (%) | |||
Mean dose | Std dev. | Mean dose | Std dev. | ||
Brain | 6.34E + 01 | 2.84E + 01 | 3.94E + 01 | 1.27E + 01 | 60.98 |
Large intestine† | 3.63E + 02 | 9.36E + 01 | 2.34E + 02 | 6.30E + 01 | 54.91 |
Small intestine† | 3.45E + 02 | 8.84E + 01 | 3.29E + 02 | 6.00E + 01 | 4.71 |
Stomach wall | 4.66E + 02 | 3.43E + 02 | 1.09E + 02 | 3.57E + 01 | 327.75 |
Heart wall† | 6.28E + 02 | 1.41E + 02 | 3.31E + 02 | 7.70E + 01 | 89.65 |
Kidneys† | 3.32E + 02 | 5.10E + 01 | 3.89E + 02 | 8.40E + 01 | − 14.65 |
Liver† | 5.90E + 02 | 1.27E + 02 | 5.24E + 02 | 9.70E + 01 | 12.60 |
Lungs† | 3.20E + 02 | 4.58E + 01 | 1.47E + 02 | 4.00E + 01 | 117.86 |
Pancreas | 2.24E + 02 | 2.56E + 01 | 3.60E + 02 | 7.50E + 01 | − 37.78 |
Skeleton | 1.11E + 02 | 2.27E + 01 | 6.57E + 01 | 1.81E + 01 | 68.99 |
Spleen | 9.48E + 01 | 2.62E + 01 | 6.92E + 02 | 1.23E + 02 | − 86.30 |
Testes | 6.68E + 01 | 2.87E + 01 | 4.10E + 01 | 1.31E + 01 | 62.87 |
Thyroid | 7.22E + 01 | 2.93E + 01 | 4.39E + 01 | 1.40E + 01 | 64.46 |
Urinary bladder | 8.85E + 01 | 3.01E + 01 | 5.13E + 01 | 1.54E + 01 | 72.56 |
Total body | 1.58E + 02 | 3.34E + 01 | 9.99E + 01 | 2.50E + 01 | 58.41 |
Tumor† | 2.14E + 02 | 6.94E + 01 | 2.60E + 02 | 7.23E + 01 | − 17.66 |