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Fig. 6 | EJNMMI Research

Fig. 6

From: Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer

Fig. 6

A representative case of a 67-year-old patient with preoperative PSA of 6.2 ng/ml. HE staining of whole-mount prostatectomy section indicates a bilobar adenocarcinoma with index lesion in the left lobe (marked with *) and another tumor in the right lobe (a). Axial PET/CT shows moderate 18F-fluciclovine uptake in the index lesion (SUVmax at 22 min = 3.2) and low uptake in the right lobe tumor (b). Low (× 10) and high (× 20) magnification images of HE-stained TMA core from the left index tumor shows Gleason 4 + 5 adenocarcinoma (c, d). Parallel sections show low ASCT2 (e, f) and LAT1 (g, h) staining intensity

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