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Table 2 Study results [18F]FDG-PET and CE-CT

From: Noninvasive assessment and quantification of tumor vascularization using [18F]FDG-PET/CT and CE-CT in a tumor model with modifiable angiogenesis—an animal experimental prospective cohort study

  H1299 A549 All tumors
Non-co-trans-plantation Co-trans-plantation p value Non-co-trans-plantation Co-trans-plantation p value Non-co-trans-plantation Co-trans-plantation p value
CE-CT
 Tumor volume cm3 1.94 (4.06) 6.98 (7.07)   0.17 (0.25) 6.95 (5.94)   0.28 (2.08) 6.98 (5.87)  
 Vital volume cm3 1.57 (3.10) 5.03 (4.73)   0.15 (0.22) 5.39 (3.93)   0.25 (1.60) 5.3 (4.62)  
 Relative vital volume % 86.61 (13.15) 74.53 (7.57) 0.036 85.71 (6.93) 80.65 (11.35) 0.008 85.71 (8.36) 77.73 (13.84) < 0.001
 CE in whole tumor % 196.76 (55.13) 269.92 (55.61) 0.004 204.83 (45.80) 270.20 (56.03) < 0.001 201.48 (46.31) 270.20 (50.20) < 0.001
 CE in vital tumor % 215.42 (87.58) 366.87 (65.43) < 0.001 217.38 (45.60) 336.54 (69.97) < 0.001 217.07 (56.05) 340.55 (78.53) < 0.001
 Mean HU in vital tumor HU 104.50 (25) 125.50 (19) 0.003 112.50 (15) 116.50 (12) 0.581 110.50 (16) 119.50 (15) 0.001
18F-FDG-PET
 Number of rats N 10 18   21 18   31 36  
 SUVmax   1.19 (1.41) 2.43 (0.71) 0.003 1.04 (0.60) 3.16 (1.23) < 0.001 1.14 (0.82) 2.76 (1.01) < 0.001
 SUVmean   1.16 (0.84) 1.80 (0.36) 0.011 1.04 (0.60) 2.04 (0.82) 0.001 1.11 (0.70) 1.89 (0.57) < 0.001
 SUVmin   1.13 (0.58) 1.41 (0.41) 0.093 1.04 (0.54) 1.45 (0.58) 0.035 1.05 (0.56) 1.44 (0.47) 0.003
 Metabolic active volume (thresh.A) cm3 0.18 (0.95) 1.54 (3.92) 0.002 0.01 (0.00) 2.66 (3.75) < 0.001 0.01 (0.20) 2.06 (3.70) < 0.001
 Relative met. Act. volume (thresh.A) % 13.39 (19.54) 26.75 (21.62) 0.188 6.25 (6.37) 38.83 (31.81) < 0.001 7.14 (11.86) 29.72 (30.30) < 0.001
 Metabolic active volume (thresh.B) cm3 1.47 (2.06) 2.54 (1.14) 0.004 0.32 (0.20) 2.29 (2.19) 0.001 0.38 (1.33) 2.42 (1.32) < 0.001
 Relative met. Act. volume (thresh.B) % 95.29 (120.29) 35.13 (16.62) 0.001 128.57 (109.85) 31.52 (14.15) < 0.001 126.32 (115.56) 33.83 (15.01) < 0.001
 Metabolic active volume (thresh.C) cm3 2.14 (3.51) 6.84 (4.31) < 0.001 0.1 (0.37) 6.69 (5.28) < 0.001 0.26 (2.60) 6.79 (4.28) < 0.001
 Relative met. Act. volume (thresh.C) % 93.64 (81.19) 81.83 (23.58) 0.833 51.35 (90.29) 87.43 (22.91) 0.111 62.5 (90.06) 86.23 (22.66) 0.196
  1. HU Hounsfield Unit, CE-CT contrast-enhanced computed tomography, [18F]FDG-PET F-18-fluorodeoxyglucose positron emission tomography, threshold A 50% of brain SUVmean, threshold B 50% of tumor SUVmaximum, threshold C 1.5 x muscle SUVmean
  2. Study results in overview. First and second column show results separated for both cell lines, third column show results for tumor cell lines merged together. Median (interquartile range)