Skip to main content
EJNMMI Research

Table 2 Study results [18F]FDG-PET and CE-CT

From: Noninvasive assessment and quantification of tumor vascularization using [18F]FDG-PET/CT and CE-CT in a tumor model with modifiable angiogenesis—an animal experimental prospective cohort study

 

H1299

A549

All tumors

Non-co-trans-plantation

Co-trans-plantation

p value

Non-co-trans-plantation

Co-trans-plantation

p value

Non-co-trans-plantation

Co-trans-plantation

p value

CE-CT

 Tumor volume

cm3

1.94 (4.06)

6.98 (7.07)

 

0.17 (0.25)

6.95 (5.94)

 

0.28 (2.08)

6.98 (5.87)

 

 Vital volume

cm3

1.57 (3.10)

5.03 (4.73)

 

0.15 (0.22)

5.39 (3.93)

 

0.25 (1.60)

5.3 (4.62)

 

 Relative vital volume

%

86.61 (13.15)

74.53 (7.57)

0.036

85.71 (6.93)

80.65 (11.35)

0.008

85.71 (8.36)

77.73 (13.84)

< 0.001

 CE in whole tumor

%

196.76 (55.13)

269.92 (55.61)

0.004

204.83 (45.80)

270.20 (56.03)

< 0.001

201.48 (46.31)

270.20 (50.20)

< 0.001

 CE in vital tumor

%

215.42 (87.58)

366.87 (65.43)

< 0.001

217.38 (45.60)

336.54 (69.97)

< 0.001

217.07 (56.05)

340.55 (78.53)

< 0.001

 Mean HU in vital tumor

HU

104.50 (25)

125.50 (19)

0.003

112.50 (15)

116.50 (12)

0.581

110.50 (16)

119.50 (15)

0.001

18F-FDG-PET

 Number of rats

N

10

18

 

21

18

 

31

36

 

 SUVmax

 

1.19 (1.41)

2.43 (0.71)

0.003

1.04 (0.60)

3.16 (1.23)

< 0.001

1.14 (0.82)

2.76 (1.01)

< 0.001

 SUVmean

 

1.16 (0.84)

1.80 (0.36)

0.011

1.04 (0.60)

2.04 (0.82)

0.001

1.11 (0.70)

1.89 (0.57)

< 0.001

 SUVmin

 

1.13 (0.58)

1.41 (0.41)

0.093

1.04 (0.54)

1.45 (0.58)

0.035

1.05 (0.56)

1.44 (0.47)

0.003

 Metabolic active volume (thresh.A)

cm3

0.18 (0.95)

1.54 (3.92)

0.002

0.01 (0.00)

2.66 (3.75)

< 0.001

0.01 (0.20)

2.06 (3.70)

< 0.001

 Relative met. Act. volume (thresh.A)

%

13.39 (19.54)

26.75 (21.62)

0.188

6.25 (6.37)

38.83 (31.81)

< 0.001

7.14 (11.86)

29.72 (30.30)

< 0.001

 Metabolic active volume (thresh.B)

cm3

1.47 (2.06)

2.54 (1.14)

0.004

0.32 (0.20)

2.29 (2.19)

0.001

0.38 (1.33)

2.42 (1.32)

< 0.001

 Relative met. Act. volume (thresh.B)

%

95.29 (120.29)

35.13 (16.62)

0.001

128.57 (109.85)

31.52 (14.15)

< 0.001

126.32 (115.56)

33.83 (15.01)

< 0.001

 Metabolic active volume (thresh.C)

cm3

2.14 (3.51)

6.84 (4.31)

< 0.001

0.1 (0.37)

6.69 (5.28)

< 0.001

0.26 (2.60)

6.79 (4.28)

< 0.001

 Relative met. Act. volume (thresh.C)

%

93.64 (81.19)

81.83 (23.58)

0.833

51.35 (90.29)

87.43 (22.91)

0.111

62.5 (90.06)

86.23 (22.66)

0.196

  1. HU Hounsfield Unit, CE-CT contrast-enhanced computed tomography, [18F]FDG-PET F-18-fluorodeoxyglucose positron emission tomography, threshold A 50% of brain SUVmean, threshold B 50% of tumor SUVmaximum, threshold C 1.5 x muscle SUVmean
  2. Study results in overview. First and second column show results separated for both cell lines, third column show results for tumor cell lines merged together. Median (interquartile range)
Back to article page