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EJNMMI Research

Table 1 Growth and histology

From: Noninvasive assessment and quantification of tumor vascularization using [18F]FDG-PET/CT and CE-CT in a tumor model with modifiable angiogenesis—an animal experimental prospective cohort study

 

H1299

A549

All tumors

Non-co-trans-plantation

Co-trans-plantation

p value

Non-co-trans-plantation

Co-trans-plantation

p value

Non-co-trans-plantation

Co-trans-plantation

p value

In vivo

 Growth duration

Days

49.00 (20)

18.0 (11)

< 0.001

45.0 (10)

23.5 (15)

< 0.001

45.9 (7)

22.0 (12)

< 0.001

In vitro

 Beads

Number/FOV

1.10 (0.28)

1.3 (0.17)

0.009

1.1 (0.22)

1.3 (0.23)

0.032

1.1 (0.25)

1.3 (0.22)

0.001

 MVD

Number/mm2

89.7 (65.49)

203.1 (185.49)

0.036

114.6 (81.98)

153.4 (112.75)

0.018

101.8 (63.3)

171.4 (120)

0.002

  1. FOV field of view, MVD microvessel density
  2. Tumor growth duration till endpoint and in vitro data derived from histology and immunohistology. Measurements were done as soon the tumors had reached a maximum diameter of 20 mm or after 48 days of growth, depending on which criterion was reached first. First and second column show results separated for both cell lines, third column show results for tumor cell lines merged together. Median (interquartile range)
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