Fig. 3

Expression profiles of commonly regulated transcripts after ¹⁷⁷Lu-octreotate therapy with priming. Differential expression (treated vs. control) of the 38 significantly regulated transcripts shared between at least two of the studied time points, after i.v. injection of 5 + 10 MBq ¹⁷⁷Lu-octreotate at 1, 3, 7, or 41 days after injection. Transcripts with fold change ≥ 1.5 and FDR-adjusted p < 0.01 were considered significantly regulated; annotation of enriched Gene Ontology terms was performed using the Gene Ontology database (modified Fisher’s exact test, threshold p < 0.05). Up- and downregulation is indicated by positive and negative values, respectively