EJNMMI Research

Table 3 Bias in DVR and outliers as a result of noise and the dual-time-window protocol for SRTM-generated [¹⁸F]flutemetamol TACs

From: Optimized dual-time-window protocols for quantitative [¹⁸F]flutemetamol and [¹⁸F]florbetaben PET studies

FLUT		% bias DVR			% outlier
	Interval	1%	2%	5%	1%	2%	5%
BP_ND I	10–90	0.0	1.9	2.0	0.0	0.0	0.0
	20–90	6.4	6.1	2.4	0.0	0.0	0.0
	30–90	0.5	0.5	3.1	0.0	0.0	0.0
	40–90	1.5	1.6	1.6	0.0	0.0	0.0
	50–90	1.5	1.5	1.7	0.0	0.0	0.0
	60–90	1.5	1.6	1.9	0.0	0.0	0.0
	70–90	1.8	2.1	0.3	0.0	0.0	0.0
	80–90	0.8	1.3	1.3	0.0	0.0	0.0
	90–90	0.0	0.0	0.0	0.0	0.0	0.0
BP_ND II	10–90	1.0	6.2	8.2	0.0	2.0	12.0
	20–90	1.5	0.2	4.0	0.0	0.0	2.0
	30–90	0.1	0.2	1.3	0.0	0.0	0.0
	40–90	0.0	0.3	0.1	0.0	0.0	0.0
	50–90	0.0	0.3	0.4	0.0	0.0	0.0
	60–90	0.0	0.2	0.6	0.0	0.0	0.0
	70–90	0.0	0.1	0.6	0.0	0.0	0.0
	80–90	0.1	0.0	0.3	0.0	0.0	0.0
	90–90	0.0	0.0	0.0	0.0	0.0	0.0
BP_ND III	10–90	0.9	1.4	2.0	0.0	10.0	34.0
	20–90	0.1	0.5	0.6	0.0	0.0	10.0
	30–90	0.1	0.3	0.3	0.0	0.0	4.0
	40–90	0.1	0.5	0.0	0.0	0.0	4.0
	50–90	0.1	0.5	0.2	0.0	0.0	4.0
	60–90	0.1	0.5	0.1	0.0	0.0	4.0
	70–90	0.1	0.4	0.3	0.0	0.0	4.0
	80–90	0.0	0.1	0.5	0.0	0.0	2.0
	90–90	0.0	0.0	0.0	0.0	0.0	2.0
BP_ND IV	10–90	1.6	2.7	1.8	0.0	2.0	32.0
	20–90	0.2	0.3	0.8	0.0	0.0	12.0
	30–90	0.0	0.0	1.3	0.0	0.0	6.0
	40–90	0.0	0.1	0.6	0.0	0.0	0.0
	50–90	0.0	0.1	0.7	0.0	0.0	0.0
	60–90	0.0	0.1	0.7	0.0	0.0	0.0
	70–90	0.1	0.2	0.7	0.0	0.0	0.0
	80–90	0.0	0.1	0.9	0.0	0.0	0.0
	90–90	0.0	0.0	0.0	0.0	0.0	0.0
BP_ND V	10–90	1.2	0.1	6.5	2.0	14.0	48.0
	20–90	0.1	0.0	0.5	0.0	0.0	22.0
	30–90	0.0	0.6	0.8	0.0	0.0	18.0
	40–90	0.0	0.5	1.0	0.0	0.0	16.0
	50–90	0.0	0.6	0.9	0.0	0.0	14.0
	60–90	0.0	0.6	0.3	0.0	0.0	12.0
	70–90	0.0	0.4	0.5	0.0	0.0	14.0
	80–90	0.0	0.2	0.4	0.0	0.0	12.0
	90–90	0.0	0.0	0.0	0.0	0.0	12.0

Bias in simulated DVR compared to full-kinetic curve DVR and % outliers across noise levels (1–5%) for [¹⁸F]flutemetamol

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