Fig. 4
From: Determination of a pharmacokinetic model for [11C]-acetate in brown adipose tissue
Pharmacokinetic models examined in this study. Cp: plasma concentration of [11C]-acetate, also known as the arterial input function or AIF. C1-C3: concentration of [11C]-acetate or its metabolites in different physical or biochemical compartments. Tissue compartments are in blue, vascular compartments are in red. K1: flow constant (mL/g/min); k2-k5: rate constants (min−1). All models also include a blood volume parameter (vb) to account for the vascular [11C]-acetate and metabolite signals. For the four-compartmental models (#5, #6, and #7), the entry and exit rates for the oxidative compartment are set to the same value