Table 1 Potencies of S01-GCG and S02-GCG at the GCGR and GLP-1R in transfected HEK293 cells
From: First-in-class positron emission tomography tracer for the glucagon receptor
Peptide | Human | Cynomolgus monkey | Rat | |||
|---|---|---|---|---|---|---|
GCGR (pM) | GLP1R (pM) | GCGR (pM) | GLP1R (pM) | GCGR (pM) | GLP1R (pM) | |
DO3A-S01-GCG | 0.4 | 19,734 | 1.2 | 4812 | 11.2 | 16,884 |
DO3A-S02-GCG | 0.8 | 4611 | 7.9 | 1980 | 47.6 | 3960 |
Native GCG | 0.5 | 28 | 1.2 | 31 | 7.5 | 39 |