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Table 1 Potencies of S01-GCG and S02-GCG at the GCGR and GLP-1R in transfected HEK293 cells

From: First-in-class positron emission tomography tracer for the glucagon receptor

Peptide Human Cynomolgus monkey Rat
GCGR (pM) GLP1R (pM) GCGR (pM) GLP1R (pM) GCGR (pM) GLP1R (pM)
DO3A-S01-GCG 0.4 19,734 1.2 4812 11.2 16,884
DO3A-S02-GCG 0.8 4611 7.9 1980 47.6 3960
Native GCG 0.5 28 1.2 31 7.5 39
  1. All values are EC50 given as pM