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Fig. 3 | EJNMMI Research

Fig. 3

From: First-in-class positron emission tomography tracer for the glucagon receptor

Fig. 3

In vitro autoradiography of [68Ga]Ga-DO3A-S01-GCG or [68Ga]Ga-DO3A-S02-GCG. Binding of [68Ga]Ga-DO3A-S01-GCG to sections of the liver (a) and pancreas (b) from NHP (n = 3), human (n = 3), or rat (n = 1), or HEK293 cells overexpressing GCGR (n = 3) (c). Representative autoradiograms of [68Ga]Ga-DO3A-S01-GCG binding in the human liver (d). Binding of [68Ga]Ga-DO3A-S02-GCG to sections of the liver (e) and pancreas (f) from NHP (n = 3), human (n = 3), or rat (n = 1), or HEK293 cells overexpressing GCGR (n = 3) (g). Representative autoradiograms of [68Ga]Ga-DO3A-S02-GCG binding in the human liver (h). The sections were incubated either with radiotracer alone (Total) or together with 10 μM GCG, 1 μM GLP-1, or 10 μM of respective tracer precursor peptide S01-GCG or S02-GCG. Stars or p values above bars indicate difference compared to the total binding

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