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Table 1 Biodistribution and in vivo blocking of 68Ga-NOTA-anti-MMR Nb in female C57BL/6 mice, 1 h p.i. The blocked group was co-injected with a 100-fold excess amount of non-labelled NOTA-anti-MMR Nb. The uptake in tissue and organs are presented as percentage of injected activity per gram of tissue (% IA/g), corrected for decay. For the gastrointestinal tract (GI) and the carcass, percentage of injected activity per gram of whole sample was calculated. Asterisks show significantly lower uptake (p ≤ 0.05)

From: Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 68Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques

Organs Non-blocked Blocked
Blood 1.4 ± 0.4 1.8 ± 0.5
Heart 2.3 ± 0.2 1.2 ± 0.3*
Lungs 1.4 ± 0.1 1.2 ± 0.0
Salivary glands 3.8 ± 0.8 1.8 ± 0.4*
Liver 15.8 ± 3.4 5.6 ± 1.1*
Pancreas 1.4 ± 0.1 1.3 ± 0.1
Stomach 2.0 ± 0.2 1.9 ± 0.2
Spleen 9.4 ± 1.7 4.5 ± 1.0*
Small intestine 2.1 ± 0.5 1.7 ± 0.5
Large intestine 3.8 ± 0.5 3.6 ± 0.3
Kidneys 144.3 ± 33.2* 301.6 ± 41.0
Fat 0.5 ± 0.1 0.3 ± 0.0*
Skin 1.5 ± 0.2 1.5 ± 0.0
Muscle 0.7 ± 0.1 0.6 ± 0.1
Bone 2.2 ± 0.2 2.1 ± 0.3
GI 4.1 ± 1.4 2.5 ± 0.6
Carcass 20.8 ± 1.1 19.2 ± 0.5