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Table 1 Biodistribution and in vivo blocking of 68Ga-NOTA-anti-MMR Nb in female C57BL/6 mice, 1 h p.i. The blocked group was co-injected with a 100-fold excess amount of non-labelled NOTA-anti-MMR Nb. The uptake in tissue and organs are presented as percentage of injected activity per gram of tissue (% IA/g), corrected for decay. For the gastrointestinal tract (GI) and the carcass, percentage of injected activity per gram of whole sample was calculated. Asterisks show significantly lower uptake (p ≤ 0.05)

From: Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 68Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques

Organs

Non-blocked

Blocked

Blood

1.4 ± 0.4

1.8 ± 0.5

Heart

2.3 ± 0.2

1.2 ± 0.3*

Lungs

1.4 ± 0.1

1.2 ± 0.0

Salivary glands

3.8 ± 0.8

1.8 ± 0.4*

Liver

15.8 ± 3.4

5.6 ± 1.1*

Pancreas

1.4 ± 0.1

1.3 ± 0.1

Stomach

2.0 ± 0.2

1.9 ± 0.2

Spleen

9.4 ± 1.7

4.5 ± 1.0*

Small intestine

2.1 ± 0.5

1.7 ± 0.5

Large intestine

3.8 ± 0.5

3.6 ± 0.3

Kidneys

144.3 ± 33.2*

301.6 ± 41.0

Fat

0.5 ± 0.1

0.3 ± 0.0*

Skin

1.5 ± 0.2

1.5 ± 0.0

Muscle

0.7 ± 0.1

0.6 ± 0.1

Bone

2.2 ± 0.2

2.1 ± 0.3

GI

4.1 ± 1.4

2.5 ± 0.6

Carcass

20.8 ± 1.1

19.2 ± 0.5