Fig. 1

Average normalized time activity curves for the different kinetic classes representing high specific uptake (n = 12), low specific uptake (n = 3), and extra cerebral uptake (n = 25). Next to the normalized time activity curve for high specific uptake averaged over all 12 dynamic [¹⁸F]DPA-714 PET scans at day 3 after LPS injection, the average normalized time activity curve for high specific uptake is presented for the two groups of animals scans at day 3, a first group of 7 animals with combined dynamic [¹⁸F]DPA-714 PET scanning and arterial blood sampling (dashed line) and a second group of 5 animals with only dynamic [¹⁸F]DPA-714 PET imaging (dotted line)