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Fig. 1 | EJNMMI Research

Fig. 1

From: Bone marrow cell homing to sites of acute tibial fracture: 89Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model

Fig. 1

BM cells labeled with 89Zr-oxine rapidly accumulate at the bone fracture. a The regimen of BM cell transfer and microPET/CT imaging in control mice and acquired images is shown. The 89Zr-oxine-labeled BM cells (2–2.3 × 107 cells at 9.65–15.7 kBq/106 cells) administered intravenously homed to the BM, spleen, and liver by day 1 and remained in these organs until day 5 (n = 4). b The day 1-tibial fracture scheme and acquired microPET/CT images are shown. The 89Zr-oxine-labeled BM cells distributed to the BM, spleen, and liver by day 1 as in the control mice. Following the tibial injury, labeled cells migrated to the fracture with peak accumulation by day 2, extending through day 5 (n = 4). c The day 0-tibial fracture scheme and acquired microPET/CT images are shown. The 89Zr-oxine-labeled BM cells transferred immediately after the fracture generation trafficked to the injury site and remained at the site until day 5 (n = 4)

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