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Table 2 Residence times, organ-absorbed doses and ED according to OLINDA/EXM 2.0 for 30-min and 1-h urinary voiding cycles in men. Extrapolated organ-absorbed doses in female and reference person are reported for 1-h urinary voiding cycle only

From: First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9

Target organ Patient cohort (n = 5 male)
Residence time (h) Male Male Female Reference
0.5 h voiding 1 h voiding 1 h voiding 1 h voiding
Mean SD Dose SD Dose SD Dose Dose
mGy/MBq mGy/MBq mGy/MBq mGy/MBq
Adrenals 2.48E-04 8.49E-05 1.48E-02 2.22E-03 1.46E-02 2.13E-03 1.57E-02 1.52E-02
Brain 1.53E-03 1.05E-03 1.71E-03 3.12E-04 1.71E-03 3.20E-04 3.62E-03 2.68E-03
Breast 1.06E-02 1.06E-02
Esophagus 1.06E-02 5.47E-04 1.06E-02 5.22E-04 1.25E-02 1.16E-02
Eyes 8.39E-03 4.70E-04 8.39E-03 4.56E-04 1.02E-02 9.32E-03
Gallbladder walla 3.60E-03 1.27E-03 2.69E-02 5.59E-03 2.69E-02 5.66E-03 2.19E-02 1.99E-02
Left colon 6.73E-03 3.33E-03 3.37E-02 9.04E-03 3.38E-02 9.01E-03 3.27E-02 3.08E-02
Small Intestinea 4.01E-02 1.71E-02 3.88E-02 1.05E-02 3.90E-02 1.04E-02 4.04E-02 3.76E-02
Stomach walla 4.79E-03 2.45E-03 1.92E-02 1.53E-03 1.92E-02 1.53E-03 2.00E-02 1.91E-02
Right colon 1.35E-02 6.66E-03 3.21E-02 1.01E-02 3.22E-02 1.01E-02 3.28E-02 3.00E-02
Rectum 6.73E-03 3.33E-03 3.18E-02 1.02E-02 3.25E-02 9.84E-03 3.58E-02 3.17E-02
Heart walla 2.16E-02 5.45E-03 2.13E-02 2.26E-03 2.13E-02 2.26E-03 2.70E-02 2.42E-02
Kidneys 2.14E-02 2.23E-03 3.48E-02 3.04E-03 3.48E-02 3.03E-03 3.31E-02 3.40E-02
Liver 3.79E-02 2.93E-03 1.41E-02 8.41E-04 1.41E-02 8.41E-04 1.85E-02 1.63E-02
Lungs 2.88E-02 5.98E-03 1.34E-02 1.95E-03 1.34E-02 1.95E-03 1.66E-02 1.50E-02
Ovaries 1.50E-02 1.49E-02
Pancreas 8.13E-02 1.95E-02 2.60E-01 6.14E-02 2.60E-01 6.14E-02 2.43E-01
Prostate 1.22E-02 5.52E-04 1.33E-02 7.91E-04 1.33E-02
Salivary glands 9.12E-03 5.06E-04 9.12E-03 4.93E-04 1.07E-02 9.93E-03
Red marrow 7.10E-03 8.59E-04 9.38E-03 4.18E-04 9.49E-03 4.06E-04 1.17E-02 1.17E-02
Osteogenic cells 6.83E-03 3.23E-04 6.89E-03 3.21E-04 7.71E-03 7.87E-03
Spleen 3.16E-03 6.73E-04 1.37E-02 1.58E-03 1.37E-02 1.58E-03 1.55E-02 1.46E-02
Testes 9.56E-03 5.28E-04 9.82E-03 5.59E-04 9.82E-03
Thymus 1.02E-02 3.99E-04 1.02E-02 3.60E-04 1.29E-02 1.15E-02
Thyroid 3.20E-04 5.00E-05 9.32E-03 8.30E-04 9.15E-03 8.21E-04 1.05E-02 9.85E-03
Urinary bladder walla 8.77E-02 1.69E-02 6.98E-02 1.26E-02 1.12E-01 1.97E-02 1.39E-01 1.25E-01
Uterus 1.78E-02 1.76E-02
Total body 1.14E-02 5.24E-04 1.17E-02 5.87E-04 1.43E-02 1.30E-02
ED ICRP 103 (mSv/MBq) 1.76E-02 1.07E-03 1.88E-02 1.16E-03 2.30E-02 2.17E-02
  1. aIrradiation from the organ content is accounted for residence time calculation