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EJNMMI Research

Table 2 Residence times, organ-absorbed doses and ED according to OLINDA/EXM 2.0 for 30-min and 1-h urinary voiding cycles in men. Extrapolated organ-absorbed doses in female and reference person are reported for 1-h urinary voiding cycle only

From: First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9

Target organ

Patient cohort (n = 5 male)

Residence time (h)

Male

Male

Female

Reference

0.5 h voiding

1 h voiding

1 h voiding

1 h voiding

Mean

SD

Dose

SD

Dose

SD

Dose

Dose

mGy/MBq

mGy/MBq

mGy/MBq

mGy/MBq

Adrenals

2.48E-04

8.49E-05

1.48E-02

2.22E-03

1.46E-02

2.13E-03

1.57E-02

1.52E-02

Brain

1.53E-03

1.05E-03

1.71E-03

3.12E-04

1.71E-03

3.20E-04

3.62E-03

2.68E-03

Breast

–

–

–

–

–

–

1.06E-02

1.06E-02

Esophagus

–

–

1.06E-02

5.47E-04

1.06E-02

5.22E-04

1.25E-02

1.16E-02

Eyes

–

–

8.39E-03

4.70E-04

8.39E-03

4.56E-04

1.02E-02

9.32E-03

Gallbladder walla

3.60E-03

1.27E-03

2.69E-02

5.59E-03

2.69E-02

5.66E-03

2.19E-02

1.99E-02

Left colon

6.73E-03

3.33E-03

3.37E-02

9.04E-03

3.38E-02

9.01E-03

3.27E-02

3.08E-02

Small Intestinea

4.01E-02

1.71E-02

3.88E-02

1.05E-02

3.90E-02

1.04E-02

4.04E-02

3.76E-02

Stomach walla

4.79E-03

2.45E-03

1.92E-02

1.53E-03

1.92E-02

1.53E-03

2.00E-02

1.91E-02

Right colon

1.35E-02

6.66E-03

3.21E-02

1.01E-02

3.22E-02

1.01E-02

3.28E-02

3.00E-02

Rectum

6.73E-03

3.33E-03

3.18E-02

1.02E-02

3.25E-02

9.84E-03

3.58E-02

3.17E-02

Heart walla

2.16E-02

5.45E-03

2.13E-02

2.26E-03

2.13E-02

2.26E-03

2.70E-02

2.42E-02

Kidneys

2.14E-02

2.23E-03

3.48E-02

3.04E-03

3.48E-02

3.03E-03

3.31E-02

3.40E-02

Liver

3.79E-02

2.93E-03

1.41E-02

8.41E-04

1.41E-02

8.41E-04

1.85E-02

1.63E-02

Lungs

2.88E-02

5.98E-03

1.34E-02

1.95E-03

1.34E-02

1.95E-03

1.66E-02

1.50E-02

Ovaries

–

–

–

–

–

–

1.50E-02

1.49E-02

Pancreas

8.13E-02

1.95E-02

2.60E-01

6.14E-02

2.60E-01

6.14E-02

2.43E-01

–

Prostate

–

–

1.22E-02

5.52E-04

1.33E-02

7.91E-04

–

1.33E-02

Salivary glands

–

–

9.12E-03

5.06E-04

9.12E-03

4.93E-04

1.07E-02

9.93E-03

Red marrow

7.10E-03

8.59E-04

9.38E-03

4.18E-04

9.49E-03

4.06E-04

1.17E-02

1.17E-02

Osteogenic cells

–

–

6.83E-03

3.23E-04

6.89E-03

3.21E-04

7.71E-03

7.87E-03

Spleen

3.16E-03

6.73E-04

1.37E-02

1.58E-03

1.37E-02

1.58E-03

1.55E-02

1.46E-02

Testes

–

–

9.56E-03

5.28E-04

9.82E-03

5.59E-04

–

9.82E-03

Thymus

–

–

1.02E-02

3.99E-04

1.02E-02

3.60E-04

1.29E-02

1.15E-02

Thyroid

3.20E-04

5.00E-05

9.32E-03

8.30E-04

9.15E-03

8.21E-04

1.05E-02

9.85E-03

Urinary bladder walla

8.77E-02

1.69E-02

6.98E-02

1.26E-02

1.12E-01

1.97E-02

1.39E-01

1.25E-01

Uterus

–

–

–

–

–

–

1.78E-02

1.76E-02

Total body

–

–

1.14E-02

5.24E-04

1.17E-02

5.87E-04

1.43E-02

1.30E-02

ED ICRP 103 (mSv/MBq)

–

–

1.76E-02

1.07E-03

1.88E-02

1.16E-03

2.30E-02

2.17E-02

  1. aIrradiation from the organ content is accounted for residence time calculation
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