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EJNMMI Research
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Table 1 Mean values (for both PET examinations) and test-retest reliability, repeatability, and precision estimated using the intra-class correlation coefficient (ICC), average absolute variability in percentage (AbsVar), and standard error of measurement (SEM) of different outcome measures derived with or without AIF. The minimum detectable difference (MD) denotes the difference (expressed as a percentage of the mean) needed between two measurements for them to be significantly different from each other

From: Test-retest reliability and convergent validity of (R)-[11C]PK11195 outcome measures without arterial input function

Measure Region Mean SD ICC AbsVar% SEM MD%
VT (2TCM) FC 0.72 0.16 0.73 15 0.08 32
GM 0.7 0.17 0.78 15 0.08 31
HIP 0.72 0.19 0.66 21 0.11 44
STR 0.76 0.17 0.44 18 0.13 46
THAL 0.77 0.22 0.69 21 0.12 43
VS (2TCM) FC 0.42 0.09 0.68 14 0.05 32
GM 0.42 0.09 0.67 15 0.05 34
HIP 0.45 0.1 0.35 21 0.08 51
STR 0.44 0.1 0.23 23 0.09 58
THAL 0.48 0.14 0.91 13 0.04 24
BPND (2TCM) FC 1.49 0.33 0.65 18 0.2 37
GM 1.62 0.4 0.31 29 0.33 56
HIP 2.02 0.77 − 0.19 50 0.84 115
STR 1.41 0.39 0.32 22 0.32 63
THAL 1.79 0.67 − 0.11 39 0.71 110
BPND (SRTM-SVCA4) FC 0.17 0.04 0.21 29 0.04 63
GM 0.21 0.06 0.34 27 0.05 59
HIP 0.17 0.09 − 0.39 83 0.1 160
STR 0.21 0.09 − 0.12 59 0.09 120
THAL 0.35 0.09 0.32 22 0.07 55
BPND (SRTMv-SVCA4) FC 0.15 0.09 − 0.49 113 0.11 194
GM 0.22 0.1 0.04 62 0.1 122
HIP 0.17 0.08 − 0.84 75 0.11 180
STR 0.2 0.1 0.79 38 0.04 60
THAL 0.36 0.12 − 0.14 46 0.13 97
BPND (SRTM-CER) FC − 0.07 0.09 0.5 160 0.06 258
GM − 0.03 0.06 0.51 277 0.04 444
HIP 0.01 0.08 0.19 181 0.07 1920
STR − 0.02 0.17 − 0.14 196 0.18 2963
THAL 0.09 0.06 0.67 494 0.04 112
SUV 40–60 min FC 10.31 3.72 0.89 19 1.26 34
GM 10.44 3.55 0.87 19 1.3 34
HIP 10.43 3.36 0.82 19 1.43 38
STR 10.27 3.64 0.8 26 1.63 44
THAL 11.36 3.81 0.84 20 1.55 38
  1. FC frontal cortex, GM gray matter, HIP hippocampus, STR striatum, THAL thalamus
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