Test-retest reliability and convergent validity of (R)-[11C]PK11195 outcome measures without arterial input function

EJNMMI Research

Table 1 Mean values (for both PET examinations) and test-retest reliability, repeatability, and precision estimated using the intra-class correlation coefficient (ICC), average absolute variability in percentage (AbsVar), and standard error of measurement (SEM) of different outcome measures derived with or without AIF. The minimum detectable difference (MD) denotes the difference (expressed as a percentage of the mean) needed between two measurements for them to be significantly different from each other

Measure	Region	Mean	SD	ICC	AbsVar%	SEM	MD%
V_T (2TCM)	FC	0.72	0.16	0.73	15	0.08	32
	GM	0.7	0.17	0.78	15	0.08	31
	HIP	0.72	0.19	0.66	21	0.11	44
	STR	0.76	0.17	0.44	18	0.13	46
	THAL	0.77	0.22	0.69	21	0.12	43
V_S (2TCM)	FC	0.42	0.09	0.68	14	0.05	32
	GM	0.42	0.09	0.67	15	0.05	34
	HIP	0.45	0.1	0.35	21	0.08	51
	STR	0.44	0.1	0.23	23	0.09	58
	THAL	0.48	0.14	0.91	13	0.04	24
BP_ND (2TCM)	FC	1.49	0.33	0.65	18	0.2	37
	GM	1.62	0.4	0.31	29	0.33	56
	HIP	2.02	0.77	− 0.19	50	0.84	115
	STR	1.41	0.39	0.32	22	0.32	63
	THAL	1.79	0.67	− 0.11	39	0.71	110
BP_ND (SRTM-SVCA4)	FC	0.17	0.04	0.21	29	0.04	63
	GM	0.21	0.06	0.34	27	0.05	59
	HIP	0.17	0.09	− 0.39	83	0.1	160
	STR	0.21	0.09	− 0.12	59	0.09	120
	THAL	0.35	0.09	0.32	22	0.07	55
BP_ND (SRTMv-SVCA4)	FC	0.15	0.09	− 0.49	113	0.11	194
	GM	0.22	0.1	0.04	62	0.1	122
	HIP	0.17	0.08	− 0.84	75	0.11	180
	STR	0.2	0.1	0.79	38	0.04	60
	THAL	0.36	0.12	− 0.14	46	0.13	97
BP_ND (SRTM-CER)	FC	− 0.07	0.09	0.5	160	0.06	258
	GM	− 0.03	0.06	0.51	277	0.04	444
	HIP	0.01	0.08	0.19	181	0.07	1920
	STR	− 0.02	0.17	− 0.14	196	0.18	2963
	THAL	0.09	0.06	0.67	494	0.04	112
SUV 40–60 min	FC	10.31	3.72	0.89	19	1.26	34
	GM	10.44	3.55	0.87	19	1.3	34
	HIP	10.43	3.36	0.82	19	1.43	38
	STR	10.27	3.64	0.8	26	1.63	44
	THAL	11.36	3.81	0.84	20	1.55	38

FC frontal cortex, GM gray matter, HIP hippocampus, STR striatum, THAL thalamus