Fig. 4

Pre-treatment with ENZ increases ¹⁷⁷Lu-PSMA617-induced DNA damage. Phospho-γH2A.X levels were flow cytometrically quantified in FNA tumor biopsies 4 h, 48 h, and 96 h following administration of ¹⁷⁷Lu-PSMA617 or vehicle, respectively. The fold-change in phospho-γH2A.X compared to baseline (day before RLT) is shown as mean ± SD. Asterisks indicate significance in ENZ+RLT-treated tumors compared to baseline (ENZ+RLT: 0 vs. 4 h, p = 0.003; 0 vs. 48 h, p < 0.0001)