Fig. 3

ARB increases PSMA at the tumor cell surface. Tumor volume of C4-2 (a) tumors was determined by CT (ENZ vs. vehicle, p = 0.05; BIC vs. vehicle, p = 0.02). ⁶⁸Ga-PSMA11 PET signal (%IA_mean/g) in C4-2 (b) tumors (ENZ vs. vehicle, p = 0.02; BIC vs. vehicle, p = n.s.). PSMA mean fluorescent intensity (MFI) is shown for each group (ENZ vs. vehicle, p = 0.03; BIC vs. vehicle, p = n.s.) (c). The fold-change during ARB treatment, related to the pre-treatment volume is shown. Data are shown as mean ± SD. Asterisks indicate significance