Fig. 1

Experimental design. a Investigation of ARB (ENZ vs. bicalutamide (BIC) vs. vehicle)-mediated PSMA upregulation in C4-2 xenografts. b Testing efficacy of pre-treatment with ENZ before PSMA-RLT in C4-2 tumors. DNA damage was assessed 4 h, 2 and 4 days post RLT by flow cytometric quantification of phospho-γH2A.X in FNA tumor biopsies