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Table 2 Cell binding and internalization of 68Ga/177Lu-10 and 68Ga/177Lu-11 compared to the reference ligands 68Ga/177Lu-PSMA I&T after 1 h on LNCaP cells (125,000/well, DMEM/F-12 + 5% BSA). Data is expressed as percentage of external reference 125I-IBA and as mean ± SD (n = 3)

From: Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity

  Cell binding (% of 125I-IBA) Internalization (% of 125I-IBA)
68Ga-PSMA I&T 65.0 ± 1.7 59.2 ± 1.7
177Lu-PSMA I&T 79.6 ± 1.1 75.5 ± 1.6
68Ga-10 112.6 ± 2.1 105.1 ± 2.1
177Lu-10 77.3 ± 0.7 71.7 ± 0.7
68Ga-11 107.6 ± 1.3 107.0 ± 1.2
177Lu-11 119.6 ± 0.6 118.6 ± 0.5