Table 2 Cell binding and internalization of 68Ga/177Lu-10 and 68Ga/177Lu-11 compared to the reference ligands 68Ga/177Lu-PSMA I&T after 1 h on LNCaP cells (125,000/well, DMEM/F-12 + 5% BSA). Data is expressed as percentage of external reference 125I-IBA and as mean ± SD (n = 3)
Cell binding (% of 125I-IBA) | Internalization (% of 125I-IBA) | |
|---|---|---|
68Ga-PSMA I&T | 65.0 ± 1.7 | 59.2 ± 1.7 |
177Lu-PSMA I&T | 79.6 ± 1.1 | 75.5 ± 1.6 |
68Ga-10 | 112.6 ± 2.1 | 105.1 ± 2.1 |
177Lu-10 | 77.3 ± 0.7 | 71.7 ± 0.7 |
68Ga-11 | 107.6 ± 1.3 | 107.0 ± 1.2 |
177Lu-11 | 119.6 ± 0.6 | 118.6 ± 0.5 |