Fig. 2From: Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in ratsTime-activity curves of 11C-erlotinib in the liver (a), kidneys (b), and lungs (c) and abdominal aorta (d) in the absence (control) and the presence of OATP inhibition with rifampicin (40 mg/kg i.v.). Corresponding exposure to tissues, expressed as area under the curve (AUC) in each organ, is reported in (e). Data are mean (n = 4) ± 1. S.D. ***, p < 0.001, n.s., non-significantBack to article page