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Table 2 Percentage of incorporation of 213BiIII by chelate ligands (pH 5.5, V = 0.1 mL, reaction time 5 min at 95 °C). Data represent mean values ± SD, n = 3

From: Efficient formation of inert Bi-213 chelates by tetraphosphorus acid analogues of DOTA: towards improved alpha-therapeutics

c [μM] DOTP DOTPH DOTPOEt DOTPI CHX-A"-DTPA DOTA
100 99.4 ± 0.3 98.7 ± 2.1 99.1 ± 0.1 99.7 ± 0.3 99.8 ± 0.1 96.9 ± 3.6
30 98.6 ± 0.9 99.0 ± 0.2 99.0 ± 1.0 98.8 ± 0.3 96.8 ± 2.4 94.3 ± 2.6
10 96.4 ± 2.3 99.1 ± 0.7 98.3 ± 0.9 94.2 ± 4.2 91.9 ± 1.9 81.1 ± 9.0
3 94.3 ± 2.1 92.7 ± 2.5 96.4 ± 0.6 92.9 ± 4.8 89.2 ± 6.9 64.1 ± 21.4
1 91.8 ± 4.0 85.4 ± 2.6 95.9 ± 0.3 88.0 ± 10.8 90.2 ± 6.6 37.4 ± 17.5
0.3 90.6 ± 3.9 79.7 ± 4.7 94.7 ± 0.7 73.6 ± 29.0 82.7 ± 5.3 14.6 ± 6.1
0.1 90.9 ± 3.2 79.0 ± 2.5 93.7 ± 2.6 31.7 ± 17.1 49.7 ± 23.1 3.8 ± 2.8
0.03 90.4 ± 4.5 72.0 ± 5.4 85.7 ± 3.9 20.2 ± 9.4 9.8 ± 9.2
0.01 89.5 ± 1.0 61.8 ± 8.7 66.2 ± 5.8 6.5 ± 4.7
0.003 56.2 ± 6.1 37.3 ± 5.5 10.5 ± 3.7
0.001 5.3 ± 4.2 0.4 ± 0.6 2.5 ± 0.7