Table 3 Estimates of the accuracy and precision of parameter values obtained from fits of the 2C3K, 2C4K, 3C5K, and 3C6K models to whole tumor TACs simulated by adding whole tumor-level noise to the ground-truth, represented as 3C5K and 3C6K model fits to real TACs. Values of MB, σB, σP, and σT are shown for fitted parameters as percentages of the mean values of directly related ground-truth parameters in the 3C5K or 3C6K models. When no directly related parameter exists, σP is listed alone as a percentage of the mean fitted parameter value
Model fitted | Fitted model parameters | |||||||
|---|---|---|---|---|---|---|---|---|
Ground-truth 3C5K model | ||||||||
 2C3K | v B–2C | K 1–2C | k 2–2C |  |  | k 3–2C |  | k flux–2C |
  MB (%) | 47 | – | – |  |  | −40 |  | 25 |
  σB (%) | 24 | – | – |  |  | 23 |  | 11 |
  σP (%) | 14 | 30 | 36 |  |  | 12 |  | 13 |
  σT (%) | 27 | – | – |  |  | 26 |  | 17 |
 2C4K | v B–2C | K 1–2C | k 2–2C |  |  | k 3–2C | k 4–2C | k flux–2C |
  MB (%) | 25 | – | – |  |  | 565 | – | 1014 |
  σB (%) | 20 | – | – |  |  | 700 | – | 1049 |
  σP (%) | 9 | 7 | 13 |  |  | 73 | 45 | 47 |
  σT (%) | 22 | – | – |  |  | 704 | – | 1050 |
 3C5K | v B | K 1 | k 2 | k 3 | k 4 | k 5 |  | k flux |
  MB (%) | 0 | − 1 | 0 | 1 | 0 | 0 |  | 0 |
  σB (%) | 4 | 1 | 2 | 4 | 3 | 1 |  | 0 |
  σP (%) | 10 | 5 | 10 | 20 | 11 | 10 |  | 6 |
  σT (%) | 10 | 5 | 10 | 20 | 12 | 10 |  | 6 |
 3C6K | v B | K 1 | k 2 | k 3 | k 4 | k 5 | k 6 | k flux |
  MB (%) | 0 | 0 | 1 | 5 | 3 | 13 | – | 13 |
  σB (%) | 4 | 1 | 2 | 7 | 5 | 17 | – | 16 |
  σP (%) | 10 | 5 | 9 | 22 | 13 | 34 | 384 | 31 |
  σT (%) | 11 | 5 | 9 | 23 | 14 | 38 | – | 35 |
Ground-truth 3C6K model | ||||||||
 2C3K | v B–2C | K 1–2C | k 2–2C |  |  | k 3–2C |  | k flux–2C |
  MB (%) | 48 | – | – |  |  | − 51 |  | 4 |
  σB (%) | 24 | – | – |  |  | 49 |  | 33 |
  σP (%) | 13 | 36 | 42 |  |  | 11 |  | 10 |
  σT (%) | 27 | – | – |  |  | 50 |  | 35 |
 2C4K | v B–2C | K 1–2C | k 2–2C |  |  | k 3–2C | k 4–2C | k flux–2C |
  MB (%) | 25 | – | – |  |  | 510 | 3173 | 914 |
  σB (%) | 20 | – | – |  |  | 748 | 3768 | 1122 |
  σP (%) | 11 | 16 | 36 |  |  | 65 | 44 | 40 |
  σT (%) | 23 | – | – |  |  | 751 | 3768 | 1123 |
 3C5K | v B | K 1 | k 2 | k 3 | k 4 | k 5 |  | k flux |
  MB (%) | 0 | − 1 | − 2 | − 5 | − 5 | − 18 |  | − 11 |
  σB (%) | 3 | 1 | 2 | 7 | 5 | 21 |  | 18 |
  σP (%) | 10 | 5 | 10 | 21 | 11 | 10 |  | 8 |
  σT (%) | 10 | 5 | 10 | 22 | 12 | 23 |  | 19 |
 3C6K | v B | K 1 | k 2 | k 3 | k 4 | k 5 | k 6 | k flux |
  MB (%) | − 1 | 0 | 1 | 4 | 3 | 8 | 86 | 6 |
  σB (%) | 3 | 1 | 2 | 5 | 4 | 9 | 131 | 8 |
  σP (%) | 10 | 5 | 9 | 21 | 13 | 27 | 164 | 22 |
  σT (%) | 10 | 5 | 9 | 21 | 13 | 29 | 210 | 24 |