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Table 3 Estimates of the accuracy and precision of parameter values obtained from fits of the 2C3K, 2C4K, 3C5K, and 3C6K models to whole tumor TACs simulated by adding whole tumor-level noise to the ground-truth, represented as 3C5K and 3C6K model fits to real TACs. Values of MB, σB, σP, and σT are shown for fitted parameters as percentages of the mean values of directly related ground-truth parameters in the 3C5K or 3C6K models. When no directly related parameter exists, σP is listed alone as a percentage of the mean fitted parameter value

From: Whole tumor kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow

Model fitted Fitted model parameters
Ground-truth 3C5K model
 2C3K v B–2C K 1–2C k 2–2C    k 3–2C   k flux–2C
  MB (%) 47    −40   25
  σB (%) 24    23   11
  σP (%) 14 30 36    12   13
  σT (%) 27    26   17
 2C4K v B–2C K 1–2C k 2–2C    k 3–2C k 4–2C k flux–2C
  MB (%) 25    565 1014
  σB (%) 20    700 1049
  σP (%) 9 7 13    73 45 47
  σT (%) 22    704 1050
 3C5K v B K 1 k 2 k 3 k 4 k 5   k flux
  MB (%) 0 − 1 0 1 0 0   0
  σB (%) 4 1 2 4 3 1   0
  σP (%) 10 5 10 20 11 10   6
  σT (%) 10 5 10 20 12 10   6
 3C6K v B K 1 k 2 k 3 k 4 k 5 k 6 k flux
  MB (%) 0 0 1 5 3 13 13
  σB (%) 4 1 2 7 5 17 16
  σP (%) 10 5 9 22 13 34 384 31
  σT (%) 11 5 9 23 14 38 35
Ground-truth 3C6K model
 2C3K v B–2C K 1–2C k 2–2C    k 3–2C   k flux–2C
  MB (%) 48    − 51   4
  σB (%) 24    49   33
  σP (%) 13 36 42    11   10
  σT (%) 27    50   35
 2C4K v B–2C K 1–2C k 2–2C    k 3–2C k 4–2C k flux–2C
  MB (%) 25    510 3173 914
  σB (%) 20    748 3768 1122
  σP (%) 11 16 36    65 44 40
  σT (%) 23    751 3768 1123
 3C5K v B K 1 k 2 k 3 k 4 k 5   k flux
  MB (%) 0 − 1 − 2 − 5 − 5 − 18   − 11
  σB (%) 3 1 2 7 5 21   18
  σP (%) 10 5 10 21 11 10   8
  σT (%) 10 5 10 22 12 23   19
 3C6K v B K 1 k 2 k 3 k 4 k 5 k 6 k flux
  MB (%) − 1 0 1 4 3 8 86 6
  σB (%) 3 1 2 5 4 9 131 8
  σP (%) 10 5 9 21 13 27 164 22
  σT (%) 10 5 9 21 13 29 210 24