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EJNMMI Research

Table 2 Binding affinities (IC50, nM) of chelator-peptide conjugates

From: The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist

Compound

IC50 (nM)*

sst1

sst2

sst3

sst4

sst5

SS-03

> 1000

1.7 ± 0.06

> 1000

404 ± 92

564 ± 174

SS-04

> 1000

5.3 ± 0.17

720 ± 74

171 ± 35

228 ± 73

DOTA-sst2-ANT [22]

> 1000

1.5 ± 0.4

> 1000

287 ± 27

> 1000

SS-28

5.2 ± 0.3

2.7 ± 0.38

7.7 ± 0.9

5.6 ± 0.4

4.0 ± 0.3

  1. *Values are IC50 in nM (mean ± SEM; n ≥ 3)
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