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Table 1 Biodistribution of 64Cu-RaftRGD, 64Cu-ATSM, and a combination of both in U87MG tumor-bearing mice

From: Uniform intratumoral distribution of radioactivity produced using two different radioagents, 64Cu-cyclam-RAFT-c(-RGDfK-)4 and 64Cu-ATSM, improves therapeutic efficacy in a small animal tumor model

Organ 3 h p.i. 24 h p.i.
64Cu-RaftRGD (a) 64Cu-ATSM (b) Combination (“a” + “b”)/2 64Cu-RaftRGD (a) 64Cu-ATSM (b) Combination (“a” + “b”)/2
Blood 0.05 ± 0.01 2.1 ± 0.12 1.15 ± 0.14*a, *b 1.08 0.04 ± 0.01 1.68 ± 0.15 0.83 ± 0.06*a, *b 0.86
Liver 8.06 ± 0.56 19.9 ± 1.41 12.8 ± 0.42*a, *b 14 5.43 ± 0.27 12.1 ± 0.69 8.48 ± 0.28*a, *b 8.77
Kidneys 11.8 ± 0.86 8.38 ± 0.49 9.55 ± 0.79†a, §b 10.1 8.42 ± 0.61 6.98 ± 0.34 7.18 ± 0.38‡a,║b 7.7
Muscles 0.4 ± 0.06 0.73 ± 0.06 0.57 ± 0.06†a, ‡b 0.57 0.24 ± 0.04 0.63 ± 0.05 0.46 ± 0.06*a, †b 0.44
Tumor 6.69 ± 0.64 15.5 ± 2.03 10.7 ± 1.05‡a, †b 11 5.18 ± 0.24 9.47 ± 0.78 7.02 ± 1.2‡a, ‡b 7.33
  1. Tissue radioactivity was assessed at 3 and 24 h p.i. and expressed as %IA/g. n = 5/group; *a, †a, ‡aP < 0.0001, 0.001, and 0.01, respectively vs. the 64Cu-RaftRGD group; *b, †b, ‡b, §bP < 0.0001, 0.001, 0.01, and 0.05, respectively or ║bP > 0.05 vs. the 64Cu-ATSM group