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Table 1 Biodistribution of 64Cu-RaftRGD, 64Cu-ATSM, and a combination of both in U87MG tumor-bearing mice

From: Uniform intratumoral distribution of radioactivity produced using two different radioagents, 64Cu-cyclam-RAFT-c(-RGDfK-)4 and 64Cu-ATSM, improves therapeutic efficacy in a small animal tumor model

Organ

3 h p.i.

24 h p.i.

64Cu-RaftRGD (a)

64Cu-ATSM (b)

Combination

(“a” + “b”)/2

64Cu-RaftRGD (a)

64Cu-ATSM (b)

Combination

(“a” + “b”)/2

Blood

0.05 ± 0.01

2.1 ± 0.12

1.15 ± 0.14*a, *b

1.08

0.04 ± 0.01

1.68 ± 0.15

0.83 ± 0.06*a, *b

0.86

Liver

8.06 ± 0.56

19.9 ± 1.41

12.8 ± 0.42*a, *b

14

5.43 ± 0.27

12.1 ± 0.69

8.48 ± 0.28*a, *b

8.77

Kidneys

11.8 ± 0.86

8.38 ± 0.49

9.55 ± 0.79†a, §b

10.1

8.42 ± 0.61

6.98 ± 0.34

7.18 ± 0.38‡a,║b

7.7

Muscles

0.4 ± 0.06

0.73 ± 0.06

0.57 ± 0.06†a, ‡b

0.57

0.24 ± 0.04

0.63 ± 0.05

0.46 ± 0.06*a, †b

0.44

Tumor

6.69 ± 0.64

15.5 ± 2.03

10.7 ± 1.05‡a, †b

11

5.18 ± 0.24

9.47 ± 0.78

7.02 ± 1.2‡a, ‡b

7.33

  1. Tissue radioactivity was assessed at 3 and 24 h p.i. and expressed as %IA/g. n = 5/group; *a, †a, ‡aP < 0.0001, 0.001, and 0.01, respectively vs. the 64Cu-RaftRGD group; *b, †b, ‡b, §bP < 0.0001, 0.001, 0.01, and 0.05, respectively or ║bP > 0.05 vs. the 64Cu-ATSM group