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Table 2 Partial Pearson correlations, controlling for body mass index, between TSPO binding and central and peripheral markers of inflammation

From: PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

 

Plasma (n = 48)

Cerebrospinal fluid (n = 20)

sgPFC

ACC

sgPFC

ACC

Interleukin 2

–

–

0.01

−0.04

Interleukin 5

–

–

− 0.59*

− 0.53*

Interleukin 6

− 0.16

− 0.15

− 0.25

−0.26

Interleukin 8

0.09

0.12

−0.19

−0.23

Brain-derived neurotrophic factor

0.25

0.23

–

–

Vascular endothelial growth factor

0.16

0.20

−0.43

−0.39

Interferon-gamma

–

–

− 0.39

−0.30

Tumor necrosis factor alpha

−0.01

0.02

–

–

C-reactive protein

−0.07

−0.08

–

–

Amyloid A1

− 0.23

−0.23

− 0.40

−0.43

Adiponectin

0.29*

0.29*

0.01

0.01

  1. sgPFC subgenual prefrontal cortex, ACC anterior cingulate cortex, – data not available
  2. *p ≤ .05