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Table 2 Partial Pearson correlations, controlling for body mass index, between TSPO binding and central and peripheral markers of inflammation

From: PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

  Plasma (n = 48) Cerebrospinal fluid (n = 20)
sgPFC ACC sgPFC ACC
Interleukin 2 0.01 −0.04
Interleukin 5 − 0.59* − 0.53*
Interleukin 6 − 0.16 − 0.15 − 0.25 −0.26
Interleukin 8 0.09 0.12 −0.19 −0.23
Brain-derived neurotrophic factor 0.25 0.23
Vascular endothelial growth factor 0.16 0.20 −0.43 −0.39
Interferon-gamma − 0.39 −0.30
Tumor necrosis factor alpha −0.01 0.02
C-reactive protein −0.07 −0.08
Amyloid A1 − 0.23 −0.23 − 0.40 −0.43
Adiponectin 0.29* 0.29* 0.01 0.01
  1. sgPFC subgenual prefrontal cortex, ACC anterior cingulate cortex, – data not available
  2. *p ≤ .05