Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

EJNMMI Research

Table 3 Comparison of ¹⁸F-FDG PET/MRI parameters according to head and neck cancer treatment failure after surgery

¹⁸F-FDG PET/MRI parameters	Treatment failure (n = 22)	No evidence of disease (n = 50)	P value
PET parameters
SUVmax	9.7 ± 3.9	9.7 ± 5.0	0.582
MTV	13.5 ± 13.3	7.5 ± 7.9	0.049*
TLG	71.8 ± 81.5	40.2 ± 52.6	0.057
MRI parameters
ADCmean	827.3 ± 232.7	972.1 ± 365.1	0.074
Combined PET/MRI parameters
(SUVmax/ADCmean) × 1000	12.8 ± 6.0	11.3 ± 6.7	0.208
(MTV/ADCmean) × 1000	17.8 ± 20.1	7.6 ± 7.3	0.018*
(TLG/ADCmean) × 1000	91.1 ± 102.9	40.0 ± 48.6	0.025*

SUVmax maximum standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, ADCmean mean apparent diffusion coefficient
*Statistically significant (P < 0.05)