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EJNMMI Research

Table 1 Tumour-to-tissue ratios for pretargeted cetuximab and trastuzumab at 4 h after the injection of [18F]TAF

From: Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

Ratio

Cetuximab 24 h, group A

Cetuximab 24 h, group B

Cetuximab 48 h, group A

Cetuximab 48 h, group B

Cetuximab 72 h, group A

Cetuximab 72 h, group B

 Tumour/blood

0.20 ± 0.03

0.26 ± 0.01

0.24 ± 0.06

0.24 ± 0.01

0.54 ± 0.09

0.77 ± 0.15

 Tumour/liver

0.49 ± 0.08

0.76 ± 0.15

0.72 ± 0.25

0.63 ± 0.09

1.31 ± 0.01

1.34 ± 0.20

 Tumour/muscle

2.12 ± 0.38

3.41 ± 0.37

2.32 ± 0.58

2.73 ± 1.17

4.54 ± 0.59

5.42 ± 0.86

   

Trastuzumab 48 h group A

Trastuzumab 48 h group B

Trastuzumab 72 h group A

Trastuzumab 72 h group B

 Tumour/blood

      

0.57 ± 0.04

0.95 ± 0.22

0.63 ± 0.14

0.73 ± 0.17

 Tumour/liver

      

1.64 ± 0.52

2.50 ± 0.71

1.84 ± 0.38

1.63 ± 0.14

 Tumour/muscle

      

2.18 ± 0.48

4.12 ± 0.51

2.37 ± 0.49

3.17 ± 0.56

  1. The same molar amount of non-radioactive TAF was given to each animal either by adding it to the [18F]TAF injection (group A, n = 4) or by giving it 5 min prior to [18F]TAF injection (group B, n = 4)
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