Fig. 5

The ex vivo biodistribution of [¹⁸F]TAF and pretargeted cetuximab (a, c) and pretargeted trastuzumab (b, d) in groups A (n = 4) and B (n = 4). In a and b, the lag time between mAb and [¹⁸F]TAF injection is 72 h. All the results presented are at 4 h after [¹⁸F]TAF injection. The same molar amount of non-radioactive TAF was given to each animal either by adding it to the [¹⁸F]TAF injection (group A) or by giving it 5 min prior to [¹⁸F]TAF injection (group B). The values represent mean ± standard deviation. %ID/g = percentage injected dose/g. S.I. = small intestine, L.I. = large intestine. *p < 0.05 and **p < 0.005 (two-tailed paired t test done with IBM SPSS Statistics 22)