Fig. 4

Time course of the progression of the [¹⁸F] VUIIS1008 and [¹⁸F] DPA-714 PET signals before and after cerebral ischemia. %ID/cm³ (mean ± SD) of [¹⁸F] VUIIS1008 and [¹⁸F] DPA-714 was quantified in the ipsilateral cortex (a), striatum (b), hippocampus (c), and thalamus (d). The upper right panels of each figure show the selected brain ROIs for the quantification defined on a slice of a MRI (T₂W) template. Rats (n = 8 per group) were repeatedly examined by PET before (day 0) and at 1, 3, 7, 14, 21, and 28 after ischemia. *p < 0.05, **p < 0.01, and ***p < 0.001 compared with control (day 0) and day 1; ^& p < 0.05, ^&& p < 0.01, and ^&&& p < 0.001 compared with day 7