Fig. 2

Time course of the progression of the [¹⁸F] VUIIS1008 and [¹⁸F] DPA-714 PET signals before and after cerebral ischemia. The infarct size was determined by MRI at 24 h after MCAO (a). %ID/cm³ (mean ± SD) of [¹⁸F] VUIIS1008 and [¹⁸F] DPA-714 was quantified in three VOIs. The entire ipsilateral cerebral hemisphere (b), contralateral hemisphere (c), and cerebellum (d) are shown. The upper right panels of each figure show the selected brain ROIs for the quantification defined on a slice of a MRI (T₂W) template. Rats (n = 8 per group) were repeatedly examined by PET before (day 0) and at 1, 3, 7, 14, 21, and 28 days after ischemia. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with control (day 0) and day 1; ^& P < 0.05, ^&& P < 0.01, and ^&&& p < 0.001 compared with day 7