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EJNMMI Research

Table 1 Distribution volume and the time stability of four 11C–radioligands to image translocator protein (TSPO)

From: Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

 

V T

BP ND

Time stabilitya of V T

Ligand

HABs

HABs

MABs

LABs

LABs

HABs after blockade

11C-(R)-PK11195

0.7

0.8

0.9

0.5

26%

27%

11C–PBR28

4.3

1.2

0.5b

Not reliably measured

Not reliably measured [6]

25%

11C–DPA-713

3.6

7.3

3.4b

1.8b

25%

13%

11C–ER176

3.3

4.2

3.4b

1.4b

~0%

6%

  1. HABs high-affinity binders, MABs mixed-affinity binders, LABs low-affinity binders, V T total distribution volume (mL ∙ cm−3), BP ND specific-to-non-displaceable uptake ratio (unitless)
  2. a% increase of V T in last 40 min of a 90-min scan (i.e., 50–90 min)
  3. bCalculated from V T in MABs or LABs and V ND measured in HABs after blockade with XBD173 (that is, these BP ND values were not measured directly by administering XBD173 in MABs and LABs)
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