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EJNMMI Research

Table 2 Summary of correlations between in vivo measurements on 68Ga-PSMA PET and ex vivo parameters

From: Potential of asphericity as a novel diagnostic parameter in the evaluation of patients with 68Ga-PSMA-HBED-CC PET-positive prostate cancer lesions

  

GSC

D’Amico classification

N-stage

PI-RADS score

ASP (%)

Rho

0.88

0.6

− 0.07

0.26

p value

p < 0.05

p < 0.05

p > 0.05

p > 0.05

CI 95%

0.78–0.94

0.32–0.78

− 0.51–0.4

− 0.11–0.57

VTV (cm3)

Rho

0.51

0.49

− 0.06

0.33

p value

p < 0.05

p < 0.05

p > 0.05

p > 0.05

CI 95%

0.23–0.72

0.17–0.71

− 0.5–0.4

− 0.04–0.62

TLB

Rho

0.43

0.38

0

0.3

p value

p < 0.05

p < 0.05

p > 0.05

p > 0.05

CI 95%

0.12–0.66

0.04–0.64

− 0.45–0.45

− 0.07–0.6

SUVmax

Rho

0.29

0.29

− 0.14

0.22

p value

p > 0.05

p > 0.05

p > 0.05

p > 0.05

CI 95%

− 0.04–0.56

− 0.06–0.58

− 0.56–0.33

− 0.15–0.54

SUVmean

Rho

0.24

0.2

0.13

0.1

p value

p > 0.05

p > 0.05

p > 0.05

p > 0.05

CI 95%

− 0.09–0.53

− 0.15–0.51

− 0.35–0.55

− 0.27–0.44

SUVpeak

Rho

0.3

0.3

− 0.05

0.13

p value

p > 0.05

p > 0.05

p > 0.05

p > 0.05

CI 95%

− 0.03–0.57

− 0.05–0.58

− 0.49–0.42

− 0.24–0.47

PSA (ng/ml)

Rho

0.27

0.15

0.07

0.12

p value

p > 0.05

p > 0.05

p > 0.05

p > 0.05

CI 95%

− 0.06–0.55

− 0.21–0.47

− 0.4–0.51

− 0.25–0.46

  1. Spearman’s rank correlation method. This table summarizes the associations between the ASP, VTV, TLB, SUVmax, SUVmean, SUVpeak and PSA in the left column and the GSc, D’Amico classification, N-stage and the PI-RADS score in the upper row using Spearman’s rank correlation method. The closest significant (p < 0.05) correlations were measured between ASP and GSc followed by a moderate correlation towards the D’Amico classification. A significant (p < 0.05) weak correlation was seen between VTV and the GSc. Statistically significant correlations (p < 0.05) are highlighted in italics. Abbreviations: ASP asphericity, VTV viable tumor volume, TLB total lesion binding rate, SUVmax maximum standardized uptake value, SUVmean mean standardized uptake value, SUVpeak peak standardized uptake value, PSA prostate-specific antigen blood level, GSc Gleason score, PI-RADS prostate imaging reporting and data system
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