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Table 2 Summary of correlations between in vivo measurements on 68Ga-PSMA PET and ex vivo parameters

From: Potential of asphericity as a novel diagnostic parameter in the evaluation of patients with 68Ga-PSMA-HBED-CC PET-positive prostate cancer lesions

   GSC D’Amico classification N-stage PI-RADS score
ASP (%) Rho 0.88 0.6 − 0.07 0.26
p value p < 0.05 p < 0.05 p > 0.05 p > 0.05
CI 95% 0.78–0.94 0.32–0.78 − 0.51–0.4 − 0.11–0.57
VTV (cm3) Rho 0.51 0.49 − 0.06 0.33
p value p < 0.05 p < 0.05 p > 0.05 p > 0.05
CI 95% 0.23–0.72 0.17–0.71 − 0.5–0.4 − 0.04–0.62
TLB Rho 0.43 0.38 0 0.3
p value p < 0.05 p < 0.05 p > 0.05 p > 0.05
CI 95% 0.12–0.66 0.04–0.64 − 0.45–0.45 − 0.07–0.6
SUVmax Rho 0.29 0.29 − 0.14 0.22
p value p > 0.05 p > 0.05 p > 0.05 p > 0.05
CI 95% − 0.04–0.56 − 0.06–0.58 − 0.56–0.33 − 0.15–0.54
SUVmean Rho 0.24 0.2 0.13 0.1
p value p > 0.05 p > 0.05 p > 0.05 p > 0.05
CI 95% − 0.09–0.53 − 0.15–0.51 − 0.35–0.55 − 0.27–0.44
SUVpeak Rho 0.3 0.3 − 0.05 0.13
p value p > 0.05 p > 0.05 p > 0.05 p > 0.05
CI 95% − 0.03–0.57 − 0.05–0.58 − 0.49–0.42 − 0.24–0.47
PSA (ng/ml) Rho 0.27 0.15 0.07 0.12
p value p > 0.05 p > 0.05 p > 0.05 p > 0.05
CI 95% − 0.06–0.55 − 0.21–0.47 − 0.4–0.51 − 0.25–0.46
  1. Spearman’s rank correlation method. This table summarizes the associations between the ASP, VTV, TLB, SUVmax, SUVmean, SUVpeak and PSA in the left column and the GSc, D’Amico classification, N-stage and the PI-RADS score in the upper row using Spearman’s rank correlation method. The closest significant (p < 0.05) correlations were measured between ASP and GSc followed by a moderate correlation towards the D’Amico classification. A significant (p < 0.05) weak correlation was seen between VTV and the GSc. Statistically significant correlations (p < 0.05) are highlighted in italics. Abbreviations: ASP asphericity, VTV viable tumor volume, TLB total lesion binding rate, SUVmax maximum standardized uptake value, SUVmean mean standardized uptake value, SUVpeak peak standardized uptake value, PSA prostate-specific antigen blood level, GSc Gleason score, PI-RADS prostate imaging reporting and data system