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Table 1 Estimated mean difference and Bland-Altman limits of agreement for the paired differences of measurements

From: Group-sequential analysis may allow for early trial termination: illustration by an intra-observer repeatability study

Number of interim analyses Estimated mean difference and Bland-Altman limits of agreement at analysis time point
Interim analysis 1 Interim analysis 2 Interim analysis 3 Final analysis
0 0.30
–1.78 to 2.38 (N = 45)
1 0.47
–2.30 to 3.24 (N = 23)
0.30
–1.78 to 2.38 (N = 45)
2 0.25
–1.53 to 2.03 (N = 15)
0.43
–2.03 to 2.89 (N = 30)
0.30
–1.78 to 2.38 (N = 45)
3 0.19
–1.85 to 2.24 (N = 11)
0.47
–2.30 to 3.24 (N = 23)
0.40
–1.92 to 2.73 (N = 34)
0.30
–1.78 to 2.38 (N = 45)