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EJNMMI Research

Table 3 Blood chemistries of non-tumor-bearing neu-N mice treated with 15 and 44 kBq of 225Ac-DOTA-anti-PD-L1 (3 mg/kg, 60 μg)

From: Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

 

Normal rangea

15 kBq

44 kBq

44 kBqb

BUN (mg/dL)

8–33

19.7 ± 4.04

29.3 ± 5.74

20.0

ALP (IU/L)

35–96

122 ± 20.6

151 ± 38.6

526

T-Pro (g/dL)

3.5–7.2

6.30 ± 0.35

6.18 ± 0.36

7.2

ALT (IU/L)

17–77

60.0 ± 26.5

49.5 ± 56.4

>1000

Cre (mg/dL)

0.2–0.9

0.63 ± 0.15

0.58 ± 0.13

0.60

Calcium (mg/dL)

7.1–10.1

8.00 ± 0.30

8.56 ± 0.56

8.90

N

N/A

3

4

1

  1. aReference values from www.ahc.umn.edu/rar/refvalues.html
  2. bMouse was sacrificed at 98 days instead of the 100-day endpoint
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