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Table 3 Blood chemistries of non-tumor-bearing neu-N mice treated with 15 and 44 kBq of 225Ac-DOTA-anti-PD-L1 (3 mg/kg, 60 μg)

From: Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

  Normal rangea 15 kBq 44 kBq 44 kBqb
BUN (mg/dL) 8–33 19.7 ± 4.04 29.3 ± 5.74 20.0
ALP (IU/L) 35–96 122 ± 20.6 151 ± 38.6 526
T-Pro (g/dL) 3.5–7.2 6.30 ± 0.35 6.18 ± 0.36 7.2
ALT (IU/L) 17–77 60.0 ± 26.5 49.5 ± 56.4 >1000
Cre (mg/dL) 0.2–0.9 0.63 ± 0.15 0.58 ± 0.13 0.60
Calcium (mg/dL) 7.1–10.1 8.00 ± 0.30 8.56 ± 0.56 8.90
N N/A 3 4 1
  1. aReference values from www.ahc.umn.edu/rar/refvalues.html
  2. bMouse was sacrificed at 98 days instead of the 100-day endpoint