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Table 1 Summary of blood pharmacokinetics

From: Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

Construct/protein dose (mg/kg) Percent Half-life (h)
111In-DTPA-anti-PD-L1-BC/1 93 7
7 32
111In-DTPA-anti-PD-L1-BC/3 95 14
5 46
111In-DTPA-anti-PD-L1-BC/10a 100 21
225Ac-DOTA-anti-PD-L1-BC/3 63 6
37 19
  1. a1-h measurement not available, blood curve was fit to a single-phase exponential function