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Table 2 Different cutoff values for tumor to normal tissue ratio according to metabolic tumor volume

From: Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected 11C-methionine uptake

MTV (cm3) AUC Optimal cutoff value Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
≤ 0.5 (n = 15) 0.840 1.23 70.0 80.0 87.5 57.1 73.3
> 0.5, ≤ 4.0 (n = 35) 0.817 1.54 77.8 76.5 77.8 76.5 77.1
> 4.0 (n = 27) 0.924 1.85 82.6 100 100 50 85.2
  1. MTV metabolic tumor volume, AUC area under the ROC curve, PPV positive predictive value, NPV negative predictive value