Fig. 1

Spatial distribution of increased ¹⁸F-florbetapir SUVRs in the MDD patients with differing levels of treatment resistance as compared with the healthy controls (HCs), as examined by statistical parametric mapping (SPM) analysis, with an uncorrected P < 0.01 and clusters consisting of a minimum of 100 contiguous voxels, which were considered to indicate a significant difference. SPM results showing relatively high amyloid loading in MDD patients with mild treatment resistance versus controls (a); MDD patients with moderate-to-severe treatment resistance versus controls (b); and MDD patients with moderate-to-severe treatment resistance versus MDD patients with mild treatment resistance (c) (P < 0.01, uncorrected, extend voxel k = 100)