Table 5 Regional binding potential (BPND or DVR–1) estimates from the different methods for the tracer dose group (n = 10). Data are expressed as mean ± SD
From: Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain
DVR–1 | BPND | |||||
|---|---|---|---|---|---|---|
Region | 2TCM | 1TCM | SA | FRTM | SRTM | SRTM-2C |
Tracer dose | ||||||
Frontal cortex | 2.09 ± 0.23 | 2.75 ± 0.36 | 1.94 ± 0.42 | 1.84 ± 0.20 | 1.92 ± 0.20 | 1.93 ± 0.20 |
Hippocampus | 1.71 ± 0.21 | 2.28 ± 0.26 | 1.69 ± 0.32 | 1.53 ± 0.19 | 1.51 ± 0.19 | 1.59 ± 0.18 |
Cerebellum | 0.75 ± 0.08 | 0.96 ± 0.14 | 0.77 ± 0.11 | 0.70 ± 0.07 | 0.68 ± 0.08 | 0.65 ± 0.08 |
Medulla | 0.09 ± 0.03 | 0.12 ± 0.03 | 0.08 ± 0.03 | 0.08 ± 0.07 | 0.07 ± 0.04 | 0.05 ± 0.03 |