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Table 5 Regional binding potential (BPND or DVR–1) estimates from the different methods for the tracer dose group (n = 10). Data are expressed as mean ± SD

From: Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

  DVR–1 BPND
Region 2TCM 1TCM SA FRTM SRTM SRTM-2C
Tracer dose       
Frontal cortex 2.09 ± 0.23 2.75 ± 0.36 1.94 ± 0.42 1.84 ± 0.20 1.92 ± 0.20 1.93 ± 0.20
Hippocampus 1.71 ± 0.21 2.28 ± 0.26 1.69 ± 0.32 1.53 ± 0.19 1.51 ± 0.19 1.59 ± 0.18
Cerebellum 0.75 ± 0.08 0.96 ± 0.14 0.77 ± 0.11 0.70 ± 0.07 0.68 ± 0.08 0.65 ± 0.08
Medulla 0.09 ± 0.03 0.12 ± 0.03 0.08 ± 0.03 0.08 ± 0.07 0.07 ± 0.04 0.05 ± 0.03