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Table 4 Bland-Altman analysis of VT, DVR–1 and BPND of animal data

From: Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

  Animal data
  % difference (95% L.A.)
VT 1TCM SA 2TCMa
Frontal cortex −0.20 (−1.93 to 1.52) −5.16 (−18.2 to 7.87)
Hippocampus −0.32 (−2.50 to 1.84) −1.43 (−10.0 to 7.15)
Cerebellum −8.01 (−19.0 to 3.01) −1.31 (−5.42 to 2.78)
Medulla −16.9 (−34.0 to 0.24) −3.54 (−14.4 to 7.32)
Pons −19.1 (−35.9 to −2.37) 0.44 (−24.2 to 25.0)
Overall −8.91 (−28.4 to 10.5) −2.20 (−16.2 to 11.8)
DVR–1 1TCM SA  
Frontal cortex 26.7 (4.74 to 48.7) −9.01 (−53.3 to 35.3)
Hippocampus 28.3 (5.72 to 50.8) −2.53 (−31.5 to 26.4)
Cerebellum 24.1 (4.75 to 43.2) 1.70 (−22.8 to 26.2)
Medulla 28.5 (−44.7 to 101) −7.02 (−49.3 to 35.3)
Pons
Overall 26.9 (−12.6 to 66.4) −4.21 (−39.8 to 31.4)
BPND FRTM SRTM SRTM-2C
Frontal cortex −12.5 (−20.3 to −4.67) −13.8 (−21.5 to 6.16) −7.74 (−15.3 to −0.22)
Hippocampus −11.0 (−17.9 to −4.05) −12.5 (−19.6 to −5.40) −7.59 (−12.9 to −2.24)
Cerebellum −6.54 (−15.9 to 2.82) −9.58 (−22.3 to 3.14) −13.7 (−29.1 to 1.72)
Medulla −25.6 (−152 to 101) −27.7 (−134 to 78.8) −66.2 (−151 to 18.8)
Pons
Overall −13.9 (−76.7 to 48.9) −15.9 (−69.6 to 37.8) −23.8 (−88.0 to 40.4)
  1. aThe 2TCM is the model of reference for comparisons. The pons is the reference region for reference-based modeling