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Table 3 Tumor-to-background ratios obtained in PC-3 PIP/flu tumor-bearing mice

From: 44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617

  15 min after injection
PSMA-ligand 44Sc-PSMA-617 177Lu-PSMA-617 68Ga-PSMA-617 68Ga-PSMA-11
 Tumor-to-blood 5.38 ± 0.90 4.45 ± 0.66 4.15 ± 0.24 6.10 ± 1.84
 Tumor-to-liver 18.8 ± 5.02 20.4 ± 5.48 6.02 ± 0.59 15.3 ± 3.96
 Tumor-to-kidney 0.97 ± 0.21 1.06 ± 0.14 1.26 ± 0.25 0.41 ± 0.14
  30 min after injection
44Sc-PSMA-617 177Lu-PSMA-617 68Ga-PSMA-617 68Ga-PSMA-11
 Tumor-to-blood 17.6 ± 1.23 16.0 ± 3.52 16.9 ± 4.22 20.5 ± 6.40
 Tumor-to-liver 55.6 ± 7.36 53.1 ± 6.68 19.0 ± 2.32 31.7 ± 2.48
 Tumor-to-kidney 1.60 ± 0.22 2.09 ± 0.24 3.62 ± 0.81 0.58 ± 0.10
  2 h after injection
44Sc-PSMA-617 177Lu-PSMA-617 68Ga-PSMA-617 68Ga-PSMA-11
 Tumor-to-blood >200 >200 >200 >200
 Tumor-to-liver >200 >200 35.2 ± 9.94 71.3 ± 7.48
 Tumor-to-kidney 7.98 ± 1.71 11.6 ± 0.87 15.9 ± 3.26 0.69 ± 0.12