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Table 2 In vitro characteristics of the radiolabeled PSMA-ligands

From: 44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617

Radioligand LogD valuesa Relative PSMA-binding affinityb
44Sc-PSMA-617 −4.21 ± 0.04 1.2
177Lu-PSMA-617 −4.18 ± 0.06 1.0
68Ga-PSMA-617 −4.30 ± 0.10 0.5
68Ga-PSMA-11 −4.82 ± 0.07 0.4
  1. aLogD values represent the average (±SD) of 3–5 independent experiments performed in triplicate
  2. bBinding affinity is the inverse molar ratio of the average KD values determined in four independent experiments performed in triplicates