44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617

EJNMMI Research

Table 2 In vitro characteristics of the radiolabeled PSMA-ligands

Radioligand	LogD values^a	Relative PSMA-binding affinity^b
⁴⁴Sc-PSMA-617	−4.21 ± 0.04	1.2
¹⁷⁷Lu-PSMA-617	−4.18 ± 0.06	1.0
⁶⁸Ga-PSMA-617	−4.30 ± 0.10	0.5
⁶⁸Ga-PSMA-11	−4.82 ± 0.07	0.4

^aLogD values represent the average (±SD) of 3–5 independent experiments performed in triplicate
^bBinding affinity is the inverse molar ratio of the average K_D values determined in four independent experiments performed in triplicates